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ex expanded [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33218, updated on 9-Dec-2024

Summary

Official Symbol
exprovided by FlyBase
Official Full Name
expandedprovided by FlyBase
Primary source
FLYBASE:FBgn0004583
Locus tag
Dmel_CG4114
See related
AllianceGenome:FB:FBgn0004583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1270; brl; CG4114; Dmel\CG4114; Ex; EX; exp; Expanded; Frmd6; l(2)01270; l(2)ey
Summary
Enables DNA-binding transcription factor binding activity; kinase binding activity; and protein sequestering activity. Involved in several processes, including border follicle cell migration; negative regulation of developmental growth; and regulation of intracellular signal transduction. Located in apicolateral plasma membrane; cytoplasmic side of apical plasma membrane; and subapical part of cell. Part of Kibra-Ex-Mer complex. Colocalizes with cell-cell junction. Is expressed in several structures, including adult tracheal system; cuboidal/columnar epithelium; embryonic/larval optic lobe; gland; and imaginal disc. Used to study cancer. Orthologous to several human genes including FRMD1 (FERM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

Location:
21C2-21C2; 2-0.7 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (431227..448701)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (431227..448701)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bardet-Biedl syndrome 8 Neighboring gene long non-coding RNA:CR43717 Neighboring gene croquemort Neighboring gene pseudo Neighboring gene shriveled

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye photoreceptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic recycling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in energy homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of imaginal disc growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hippo signaling IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Kibra-Ex-Mer complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Kibra-Ex-Mer complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in subapical part of cell IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
expanded
Names
CG4114-PA
CG4114-PB
braille
ex-PA
ex-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    431227..448701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057492.4NP_476840.2  expanded, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476840.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07436, Q9VPQ0
    UniProtKB/TrEMBL
    M9PC08
    Related
    FBpp0077719
    Conserved Domains (5) summary
    PHA03255
    Location:512681
    PHA03255; BDLF3; Provisional
    smart00295
    Location:27297
    B41; Band 4.1 homologues
    cd13185
    Location:298405
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    pfam00373
    Location:132305
    FERM_M; FERM central domain
    pfam09379
    Location:4098
    FERM_N; FERM N-terminal domain
  2. NM_001272894.1NP_001259823.1  expanded, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07436, Q9VPQ0
    UniProtKB/TrEMBL
    M9PC08
    Conserved Domains (5) summary
    PHA03255
    Location:512681
    PHA03255; BDLF3; Provisional
    smart00295
    Location:27297
    B41; Band 4.1 homologues
    cd13185
    Location:298405
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
    pfam00373
    Location:132305
    FERM_M; FERM central domain
    pfam09379
    Location:4098
    FERM_N; FERM N-terminal domain