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shv shriveled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33220, updated on 4-Jan-2025

Summary

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Official Symbol
shvprovided by FlyBase
Official Full Name
shriveledprovided by FlyBase
Primary source
FLYBASE:FBgn0031256
Locus tag
Dmel_CG4164
See related
AllianceGenome:FB:FBgn0031256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4164; Dmel\CG4164
Summary
Enables integrin binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; male germ-line stem cell population maintenance; and positive regulation of integrin-mediated signaling pathway. Located in extracellular space and neuromuscular junction. Is expressed in several structures, including adult head; circulatory system primordium; ganglia; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See shv in Genome Data Viewer
Location:
21C2-21C2; 2-0.7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (453108..454654)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (453108..454654)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene expanded Neighboring gene long non-coding RNA:CR43717 Neighboring gene croquemort Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. Lee JY, et al. J Neurosci, 2017 Mar 22. PMID 28219985, Free PMC Article
  2. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. Lee JY, et al. PLoS Genet, 2016 May. PMID 27191715, Free PMC Article
  3. Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling. Chang YC, et al. Proc Natl Acad Sci U S A, 2024 Apr 16. PMID 38588427, Free PMC Article
  4. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila. Desai M, et al. PLoS Biol, 2024 Apr. PMID 38648719, Free PMC Article
  5. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Uytterhoeven V, et al. Neuron, 2015 Nov 18. PMID 26590345

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shriveled
Names
CG4164-PA
shv-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    453108..454654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134681.3 → NP_608525.1  shriveled [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608525.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VPQ2
    Related
    FBpp0077720
    Conserved Domains (4) summary
    cd10747
    Location:131 → 328
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:22 → 346
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:25 → 87
    DnaJ; DnaJ domain
    cl21539
    Location:160 → 195
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPQ2.1 Q9VPQ2

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