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cold coiled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33237, updated on 4-Jan-2025

Summary

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Official Symbol
coldprovided by FlyBase
Official Full Name
coiledprovided by FlyBase
Primary source
FLYBASE:FBgn0031268
Locus tag
Dmel_CG2813
See related
AllianceGenome:FB:FBgn0031268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg2813; CG2813; Dmel\CG2813; leaky4
Summary
Involved in several processes, including establishment of blood-brain barrier; regulation of tube size, open tracheal system; and septate junction assembly. Located in cytoplasm. Is expressed in several structures, including adult brain cell body rind; adult heart; ectodermal derivative; epidermis; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cold in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (574291..575734)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (574291..575734)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2 Neighboring gene Prothoracicotropic hormone Neighboring gene PvuII-PstI homology 13 Neighboring gene Goosecoid Neighboring gene long non-coding RNA:CR46148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. Hijazi A, et al. PLoS One, 2011 Mar 15. PMID 21423573, Free PMC Article
  2. The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila. Syed MH, et al. J Neurosci, 2011 May 25. PMID 21613501, Free PMC Article
  3. Occluding junctions as novel regulators of tissue mechanics during wound repair. Carvalho L, et al. J Cell Biol, 2018 Dec 3. PMID 30228162, Free PMC Article
  4. ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells. Esmangart de Bournonville T, et al. Elife, 2024 Feb 2. PMID 38305711, Free PMC Article
  5. microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein. Pinder BD, et al. EMBO Rep, 2013 Jan. PMID 23184089, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in establishment of blood-brain barrier IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of blood-brain barrier IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coiled
Names
CG2813-PA
CG2813-PB
cold-PA
cold-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    574291..575734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272909.1 → NP_001259838.1  coiled, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259838.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VPR7
    Conserved Domains (1) summary
    cl10471
    Location:26 → 119
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

  2. NM_134692.5 → NP_608536.1  coiled, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VPR7
    Related
    FBpp0077729
    Conserved Domains (1) summary
    cl10471
    Location:26 → 119
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPR7 Q9VPR7
Q9VPR7.1

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