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ds - dachsous

Enables cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; establishment of planar polarity; and regulation of hippo signaling. Located in apicolateral plasma membrane. Is expressed in several structures, including embryonic/larval head sense organ; epithelium; gut section; imaginal disc; and organism subdivision. Used to study obesity. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to several human genes including DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa