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Tmtc2 Transmembrane O-mannosyltransferase targeting cadherins 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33276, updated on 4-Jan-2025

Summary

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Official Symbol
Tmtc2provided by FlyBase
Official Full Name
Transmembrane O-mannosyltransferase targeting cadherins 2provided by FlyBase
Primary source
FLYBASE:FBgn0028481
Locus tag
Dmel_CG4341
See related
AllianceGenome:FB:FBgn0028481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH12144; CG4341; Dmel\CG4341; TMTC2
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in spermatozoon. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Tmtc2 in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (922793..958098)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (922793..958098)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44061 Neighboring gene Glutamate receptor IIC Neighboring gene long non-coding RNA:CR44801 Neighboring gene antisense RNA:CR46486 Neighboring gene IA-2 protein tyrosine phosphatase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
  2. A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster. Hope KA, et al. Sci Rep, 2019 Feb 20. PMID 30787400, Free PMC Article
  3. A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines. Bollepogu Raja KK, et al. Nat Commun, 2023 Nov 8. PMID 37938573, Free PMC Article
  4. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
  5. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane O-mannosyltransferase targeting cadherins 2
Names
CG4341-PA
CG4341-PC
Tmtc2-PA
Tmtc2-PC
NP_001097048.2
NP_608558.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    922793..958098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134714.5 → NP_608558.1  transmembrane O-mannosyltransferase targeting cadherins 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608558.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3X5
    Related
    FBpp0077614
    Conserved Domains (5) summary
    sd00006
    Location:602 → 630
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:636 → 668
    TPR_1; Tetratricopeptide repeat
    pfam08409
    Location:275 → 343
    DUF1736; Domain of unknown function (DUF1736)
    pfam13414
    Location:602 → 667
    TPR_11; TPR repeat
    cl21590
    Location:112 → 232
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. NM_001103578.3 → NP_001097048.2  transmembrane O-mannosyltransferase targeting cadherins 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097048.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYS8
    Conserved Domains (5) summary
    sd00006
    Location:572 → 600
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:606 → 638
    TPR_1; Tetratricopeptide repeat
    pfam08409
    Location:245 → 313
    DUF1736; Domain of unknown function (DUF1736)
    pfam13414
    Location:572 → 637
    TPR_11; TPR repeat
    cl21590
    Location:82 → 202
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYS8 A8DYS8
Q9V3X5.1 Q9V3X5

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