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MFS3 Major Facilitator Superfamily Transporter 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33292, updated on 9-Dec-2024

Summary

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Official Symbol
MFS3provided by FlyBase
Official Full Name
Major Facilitator Superfamily Transporter 3provided by FlyBase
Primary source
FLYBASE:FBgn0031307
Locus tag
Dmel_CG4726
See related
AllianceGenome:FB:FBgn0031307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4726; Dmel\CG4726; Mfs3
Summary
Enables D-glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; gut section; larval somatic muscle cell; and tracheal primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MFS3 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1143201..1147395)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1143201..1147395)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 23 Neighboring gene iris Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene lethal (2) 10685 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. McMullen E, et al. Front Behav Neurosci, 2020. PMID 33551766, Free PMC Article
  2. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. Freije WA, et al. G3 (Bethesda), 2012 Aug. PMID 22908033, Free PMC Article
  3. Glucose and trehalose metabolism through the cyclic pentose phosphate pathway shapes pathogen resistance and host protection in Drosophila. Kazek M, et al. PLoS Biol, 2024 May. PMID 38713712, Free PMC Article
  4. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
  5. A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies. Nixon KCJ, et al. Am J Hum Genet, 2019 Apr 4. PMID 30879640, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables trehalose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
major facilitator superfamily transporter 3
Names
CG4726-PA
MFS3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1143201..1147395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134728.2 → NP_608572.1  major facilitator superfamily transporter 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPX2
    Related
    FBpp0077623
    Conserved Domains (2) summary
    cd06174
    Location:100 → 479
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:19 → 489
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPX2 Q9VPX2

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