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l(2)10685 lethal (2) 10685 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33293, updated on 4-Jan-2025

Summary

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Official Symbol
l(2)10685provided by FlyBase
Official Full Name
lethal (2) 10685provided by FlyBase
Primary source
FLYBASE:FBgn0283525
Locus tag
Dmel_CG4749
See related
AllianceGenome:FB:FBgn0283525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.81; CG4749; Dmel\CG4749
Summary
Predicted to enable rRNA methyltransferase activity. Predicted to be involved in mitochondrial RNA modification and rRNA methylation. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See l(2)10685 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1147822..1149449)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1147822..1149449)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF. Ida H, et al. Nucleic Acids Res, 2009 Apr. PMID 19136464, Free PMC Article
  2. Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Stathopoulos A, et al. Cell, 2002 Nov 27. PMID 12464180
  3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  4. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article
  5. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Spradling AC, et al. Genetics, 1999 Sep. PMID 10471706, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lethal (2) 10685
Names
CG4749-PA
l(2)10685-PA
NP_608573.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1147822..1149449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134729.3 → NP_608573.1  lethal (2) 10685 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPX3
    Related
    FBpp0077624
    Conserved Domains (1) summary
    cl17173
    Location:283 → 499
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPX3 Q9VPX3

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