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Charon charon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33303, updated on 4-Jan-2025

Summary

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Official Symbol
Charonprovided by FlyBase
Official Full Name
charonprovided by FlyBase
Primary source
FLYBASE:FBgn0031317
Locus tag
Dmel_CG5118
See related
AllianceGenome:FB:FBgn0031317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.11; CG5118; Dmel\CG5118; pickle
Summary
Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription repressor activity; and NF-kappaB binding activity. Involved in defense response to other organism; regulation of DNA-templated transcription; and regulation of peptidoglycan recognition protein signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Charon in Genome Data Viewer
Location:
21F2-21F2; 2-2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1170753..1172805, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1170753..1172805, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Integrator 14 Neighboring gene uncharacterized protein Neighboring gene Phospholipase A2 activator protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila. Ji Y, et al. J Immunol, 2016 Sep 15. PMID 27527593, Free PMC Article
  2. Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior. Chandler JA, et al. iScience, 2022 Apr 15. PMID 35313693, Free PMC Article
  3. Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense. Morris O, et al. Cell Host Microbe, 2016 Sep 14. PMID 27631699, Free PMC Article
  4. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Goto A, et al. Immunity, 2018 Aug 21. PMID 30119996, Free PMC Article
  5. NF-κB disinhibition contributes to dendrite defects in fly models of neurodegenerative diseases. Han MH, et al. J Cell Biol, 2020 Dec 7. PMID 33090185, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NF-kappaB binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
charon
Names
CG5118-PA
Charon-PA
pickle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1170753..1172805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134737.4 → NP_608581.2  charon [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608581.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRJ4, Q9VPY3
    Related
    FBpp0077644
    Conserved Domains (4) summary
    COG0666
    Location:216 → 400
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:300 → 394
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:340 → 488
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:335 → 369
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPY3 Q9VPY3

Gene LinkOut

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