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Der-1 Derlin-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33369, updated on 9-Dec-2024

Summary

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Official Symbol
Der-1provided by FlyBase
Official Full Name
Derlin-1provided by FlyBase
Primary source
FLYBASE:FBgn0267972
Locus tag
Dmel_CG10908
See related
AllianceGenome:FB:FBgn0267972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10908; dDer-1; Dmel\CG10908; l(2)SH1964; l(2)SH2 1964
Summary
Predicted to enable signal recognition particle binding activity. Involved in positive regulation of apoptotic process and response to endoplasmic reticulum stress. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval garland cell; embryonic/larval salivary gland; and garland cell primordium. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Der-1 in Genome Data Viewer
Location:
22B8-22B8; 2-3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1973957..1975413)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1973957..1975413)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene earmuff Neighboring gene transfer RNA:Arginine-TCT 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis. Liu F, et al. J Genet Genomics, 2022 Mar. PMID 34547438
  2. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
  3. Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. Lemberg MK, et al. EMBO J, 2005 Feb 9. PMID 15616571, Free PMC Article
  4. Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster. Pedersen KS, et al. Genetics, 2008 Oct. PMID 18791253, Free PMC Article
  5. Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. Liang CJ, et al. PLoS Genet, 2014 Sep. PMID 25255315, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal recognition particle binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Derlin-1
Names
CG10908-PA
CG10908-PB
Der-1-PA
Der-1-PB
Dm Derlin-1
derlin-1
lethal (2) SH1964

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1973957..1975413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272963.1 → NP_001259892.1  Derlin-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259892.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ57
    UniProtKB/TrEMBL
    M9PBP5
    Conserved Domains (1) summary
    pfam04511
    Location:10 → 202
    DER1; Der1-like family

  2. NM_134788.4 → NP_608632.1  Derlin-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ57
    UniProtKB/TrEMBL
    M9PBP5
    Related
    FBpp0077489
    Conserved Domains (1) summary
    pfam04511
    Location:10 → 202
    DER1; Der1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBP5 M9PBP5
Q9VQ57.1 Q9VQ57

Gene LinkOut

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