U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AIF Apoptosis inducing factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33390, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
AIFprovided by FlyBase
Official Full Name
Apoptosis inducing factorprovided by FlyBase
Primary source
FLYBASE:FBgn0031392
Locus tag
Dmel_CG7263
See related
AllianceGenome:FB:FBgn0031392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aif; CG7263; dAIF; DmAIF; Dmel\CG7263; SD03428p
Summary
Predicted to enable DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including defense response to fungus; mitochondrial ATP synthesis coupled electron transport; and mitochondrial disulfide relay system. Located in mitochondrial intermembrane space. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AIF in Genome Data Viewer
Location:
22D1-22D1; 2-5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2151754..2155389)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2151754..2155389)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tubulin-binding cofactor D Neighboring gene uncharacterized protein Neighboring gene anterior open Neighboring gene long non-coding RNA:CR43751

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles. Murari A, et al. STAR Protoc, 2021 Dec 17. PMID 34977670, Free PMC Article
  2. The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Trotta N, et al. Curr Biol, 2004 Jul 13. PMID 15242610
  3. In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury. Constantinou C, et al. Int J Mol Med, 2016 Feb. PMID 26648055, Free PMC Article
  4. The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Joza N, et al. Cell Death Differ, 2008 Jun. PMID 18309327, Free PMC Article
  5. Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis. Okumura M, et al. J Neurosci, 2015 Feb 4. PMID 25653356, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables DNA binding IKR
Inferred from Key Residues
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD(P)H oxidase H2O2-forming activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)H oxidase H2O2-forming activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial disulfide relay system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial intermembrane space IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
apoptosis inducing factor
Names
AIF-PA
AIF-PB
AIF-PC
CG7263-PA
CG7263-PB
CG7263-PC
NP_001259907.1
NP_608649.2
NP_722765.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2151754..2155389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272978.1 → NP_001259907.1  apoptosis inducing factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH83, M9PBQ4
    Conserved Domains (3) summary
    pfam00070
    Location:426 → 511
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:256 → 572
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:590 → 719
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

  2. NM_134805.4 → NP_608649.2  apoptosis inducing factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608649.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH83
    Related
    FBpp0077503
    Conserved Domains (3) summary
    pfam00070
    Location:362 → 447
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:192 → 508
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:526 → 655
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

  3. NM_164456.3 → NP_722765.2  apoptosis inducing factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722765.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIR8, Q95TL9, Q960F8, Q9VQ79
    UniProtKB/TrEMBL
    E8NH83
    Related
    FBpp0077504
    Conserved Domains (3) summary
    pfam00070
    Location:427 → 512
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:257 → 573
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:591 → 720
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBQ4 M9PBQ4
Q9VQ79.2 Q9VQ79

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools