U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eogt EGF-domain O-GlcNAc transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33424, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Eogtprovided by FlyBase
Official Full Name
EGF-domain O-GlcNAc transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0264672
Locus tag
Dmel_CG9867
See related
AllianceGenome:FB:FBgn0264672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9867; Dmel\CG9867; eogt; EOGT
Summary
Enables protein O-acetylglucosaminyltransferase activity. Involved in larval chitin-based cuticle development and protein O-GlcNAcylation via threonine. Located in endoplasmic reticulum lumen. Is expressed in embryonic/larval garland cell; garland cell primordium; and organism. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eogt in Genome Data Viewer
Location:
22E1-22E1; 2-6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2381097..2383073)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2381097..2383073)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44982 Neighboring gene uncharacterized protein Neighboring gene Ataxin 7 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. N-acetylglucosamine modification in the lumen of the endoplasmic reticulum. Ogawa M, et al. Biochim Biophys Acta, 2015 Jun. PMID 25791024
  2. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article
  3. Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease. Ogawa M, et al. World J Biol Chem, 2014 May 26. PMID 24921011, Free PMC Article
  4. O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Sakaidani Y, et al. Nat Commun, 2011 Dec 13. PMID 22158438
  5. EOGT and O-GlcNAc on secreted and membrane proteins. Varshney S, et al. Biochem Soc Trans, 2017 Apr 15. PMID 28408480, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-GlcNAcylation via threonine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-GlcNAcylation via threonine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
EGF-domain O-GlcNAc transferase
Names
CG9867-PA
CG9867-PB
EGF-domain specific O-GlcNAc transferase
Eogt-PA
Eogt-PB
NP_001259934.1
NP_608678.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2381097..2383073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134834.3 → NP_608678.1  EGF-domain O-GlcNAc transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608678.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQB7
    UniProtKB/TrEMBL
    M9PBV8
    Related
    FBpp0077447
    Conserved Domains (1) summary
    pfam04577
    Location:232 → 454
    DUF563; Protein of unknown function (DUF563)

  2. NM_001273005.1 → NP_001259934.1  EGF-domain O-GlcNAc transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQB7
    UniProtKB/TrEMBL
    M9PBV8
    Conserved Domains (1) summary
    pfam04577
    Location:232 → 454
    DUF563; Protein of unknown function (DUF563)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBV8 M9PBV8
Q9VQB7.1 Q9VQB7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools