buc bucky ball [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bucprovided by ZNC
Official Full Name: bucky ballprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070117-694
See related: Ensembl:ENSDARG00000096095 AllianceGenome:ZFIN:ZDB-GENE-070117-694
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi43g04
Summary: Acts upstream of or within morphogenesis of follicular epithelium; oocyte animal/vegetal axis specification; and pole plasm assembly. Predicted to be located in cleavage furrow and cytoplasm. Is expressed in blastomere; female organism; germ line cell; and unfertilized egg. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (27855108..27859195)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (28199472..28203559)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator.
Title: Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator.
Study data reveals a novel and essential role for rbpms2 in Zebrafish oogenesis and Bucky ball organization within early oocytes.
Title: rbpms2 functions in Balbiani body architecture and ovary fate.
that the multi-tudor domain-containing protein Tdrd6a interacts with Buc, affecting its mobility and aggregation properties
Title: Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification.
The results show that Buc-GFP exerts all biochemical interactions essential for germline development and highlight the potential of this line to analyze the molecular regulation of germ plasm formation.
Title: A functional Bucky ball-GFP transgene visualizes germ plasm in living zebrafish.
The maternally expressed zebrafish Kinesin-1 Kif5Ba is a binding partner of Buc and that maternal kif5Ba (Mkif5Ba) plays an essential role in germline specification in vivo.
Title: Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis.
Study shows that the bucky ball gene in the zebrafish is required to assemble the Balbiani body; in the absence of bucky ball the Balbiani body fails to form, and vegetal mRNAs are not localized in oocytes.[bucky ball]
Title: Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish.
Buc establishes oocyte polarity through interactions with RNA-binding proteins, initiating a feedback amplification mechanism in which Buc recruits RNA-binding proteins that in turn recruit buc and other RNAs to the Balbiani body.
Title: Oocyte polarity requires a Bucky ball-dependent feedback amplification loop.
These results identify Bucky ball (buc) as the first gene necessary and sufficient for germ plasm organization in vertebrates.
Title: Bucky ball organizes germ plasm assembly in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte animal/vegetal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bucky ball

Names: prion-like protein Bucky ball

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.