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SIFa SIFamide [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3346202, updated on 4-Jan-2025

Summary

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Official Symbol
SIFaprovided by FlyBase
Official Full Name
SIFamideprovided by FlyBase
Primary source
FLYBASE:FBgn0053527
Locus tag
Dmel_CG33527
See related
AllianceGenome:FB:FBgn0053527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33527; Dmel\CG33527; Drm-IFa; Drm-SIFa; IFa; IFAMIDE; Neb-LFamide; SIF; SIFR
Summary
Enables neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including mating behavior, sex discrimination; negative regulation of female receptivity; and neuropeptide signaling pathway. Predicted to be located in extracellular space. Is expressed in several structures, including adult brain; adult pars intercerebralis; larval central nervous system; neurosecretory cell of pars intercerebralis; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See SIFa in Genome Data Viewer
Location:
60D5-60D5; 2-107 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24577566..24578143, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20465089..20465666, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene unconventional prefoldin RPB5 interactor Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene Start1 Neighboring gene uncharacterized protein Neighboring gene piopio

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SIFamide is a highly conserved neuropeptide: a comparative study in different insect species. Verleyen P, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219831
  2. Optogenetic activation of SIFamide (SIFa) neurons induces a complex sleep-promoting effect in the fruit fly Drosophila melanogaster. Huang H, et al. Physiol Behav, 2021 Oct 1. PMID 34175361, Free PMC Article
  3. SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila. Park S, et al. Mol Cells, 2014 Apr. PMID 24658384, Free PMC Article
  4. The neuropeptide SIFamide modulates sexual behavior in Drosophila. Terhzaz S, et al. Biochem Biophys Res Commun, 2007 Jan 12. PMID 17126293
  5. The Drosophila circuitry of sleep-wake regulation. Artiushin G, et al. Curr Opin Neurobiol, 2017 Jun. PMID 28366532, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate that thermogenetic manipulations of PI neurons expressing the neuropeptide SIFamide (SIFa) as well as mutations of the SIFa gene degrade feeding:fasting rhythms. In contrast, manipulations of a nearby population of PI neurons that express the Drosophila insulin-like peptides (DILPs) affect total food consumption but leave feeding rhythms intact
    Title: A circadian output center controlling feeding:fasting rhythms in Drosophila.
  2. SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster.
    Title: SIFamide acts on fruitless neurons to modulate sexual behavior in Drosophila melanogaster.
  3. signaling promotes sleep
    Title: SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables neuropeptide hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neuropeptide receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mating behavior, sex discrimination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
SIFamide
Names
AYRKPPFNGSLFamide
CG33527-PB
IFamide
Neb-LFamide
SIFa-PB
neuropeptide AYRKPPFNGSIFamide
neuropeptide IFamide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24577566..24578143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259567.2 → NP_001246496.1  SIFamide [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246496.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E6Z0, A8E728, B3DMR1, Q6IGX9, Q8IA34
    UniProtKB/TrEMBL
    A0A1B2AKW2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IGX9.1 Q6IGX9

Gene LinkOut

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