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CG2964 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33475, updated on 4-Jan-2025

Summary

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Official Symbol
CG2964provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031462
Locus tag
Dmel_CG2964
See related
AllianceGenome:FB:FBgn0031462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2964
Summary
Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG2964 in Genome Data Viewer
Location:
23B2-23B2; 2-7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2812437..2814429)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2812437..2814429)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821 Neighboring gene dawdle Neighboring gene Glucose-6-Phosphatase Neighboring gene Dual oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
  2. Efficient identification of Y chromosome sequences in the human and Drosophila genomes. Carvalho AB, et al. Genome Res, 2013 Nov. PMID 23921660, Free PMC Article
  3. Potential involvement of Drosophila flightless-1 in carbohydrate metabolism. Park JE, et al. BMB Rep, 2018 Sep. PMID 30060781, Free PMC Article
  4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
  5. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pyruvate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pyruvate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2964-PA
NP_608713.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2812437..2814429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134869.3 → NP_608713.2  uncharacterized protein Dmel_CG2964 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608713.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T434, Q9VQH0
    Related
    FBpp0077406
    Conserved Domains (2) summary
    TIGR01064
    Location:32 → 512
    pyruv_kin; pyruvate kinase
    cl23794
    Location:32 → 515
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T434 Q8T434
Q9VQH0 Q9VQH0

Gene LinkOut

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