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Prx6a Peroxiredoxin 6a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33493, updated on 4-Jan-2025

Summary

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Official Symbol
Prx6aprovided by FlyBase
Official Full Name
Peroxiredoxin 6aprovided by FlyBase
Primary source
FLYBASE:FBgn0031479
Locus tag
Dmel_CG3083
See related
AllianceGenome:FB:FBgn0031479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153181_at; CG3083; Dmel\CG3083; dPRDX6; dPRDX6-1; dPrx6b; DPx-6005; DPx6005; GM04269p; Prx6005
Summary
Enables peroxiredoxin activity. Involved in hydrogen peroxide catabolic process. Located in cytosol. Is expressed in adult head and organism. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Prx6a in Genome Data Viewer
Location:
23C1-23C1; 2-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2877091..2878232, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2877091..2878232, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Interferon-related developmental regulator 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene Sabbat Neighboring gene NTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The involvement of Importin-β and peroxiredoxin-6005 in mitochondrial biogenesis. Villanyi Z, et al. Mech Dev, 2011 Mar-Apr. PMID 21272635
  2. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Peterson TM, et al. Free Radic Biol Med, 2006 Mar 15. PMID 16540402, Free PMC Article
  3. The peroxiredoxin gene family in Drosophila melanogaster. Radyuk SN, et al. Free Radic Biol Med, 2001 Nov 1. PMID 11677042
  4. Beyond ROS clearance: Peroxiredoxins in stress signaling and aging. Detienne G, et al. Ageing Res Rev, 2018 Jul. PMID 29580920
  5. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. peroxiredoxin-6005 is engaged in mitochondrial biogenesis possibly as a component of redox-signaling
    Title: The involvement of Importin-β and peroxiredoxin-6005 in mitochondrial biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peroxiredoxin 6a
Names
CG3083-PA
Prx6a-PA
peroxiredoxin 6005
NP_523463.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2877091..2878232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078739.3 → NP_523463.2  peroxiredoxin 6a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523463.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SB0, Q9GPQ2, Q9VQI7
    Related
    FBpp0077368
    Conserved Domains (2) summary
    COG0450
    Location:8 → 198
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03016
    Location:8 → 220
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SB0 Q95SB0
Q9GPQ2 Q9GPQ2
Q9VQI7 Q9VQI7

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