HTR1B 5-hydroxytryptamine receptor 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: HTR1Bprovided by HGNC
Official Full Name: 5-hydroxytryptamine receptor 1Bprovided by HGNC
Primary source: HGNC:HGNC:5287
See related: Ensembl:ENSG00000135312 MIM:182131; AllianceGenome:HGNC:5287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta
Summary: The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]
Orthologs: mouse all
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Genomic context

Location:: 6q14.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (77460924..77463491, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (78638386..78640951, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (78170641..78173208, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased mRNA expression for serotonin receptor 1B (HTR1B) is associated with thrombosis in BCR::ABL1-negative myeloproliferative neoplasms.
Title: Increased mRNA expression for serotonin receptor 1B (HTR1B) is associated with thrombosis in BCR::ABL1-negative myeloproliferative neoplasms.
Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
Title: Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia.
The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study.
Title: The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with lifelong premature ejaculation: a genetic case-control association study.
Synergistic Interaction of 5-HT1B and 5-HT2B Receptors in Cytoplasmic Ca[2+] Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.
Title: Synergistic Interaction of 5-HT(1B) and 5-HT(2B) Receptors in Cytoplasmic Ca(2+) Regulation in Human Umbilical Vein Endothelial Cells: Possible Involvement in Pathologies.
HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment.
Title: HTR1B genotype and psychopathy: Main effect and interaction with paternal maltreatment.
Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder.
Title: Methylation and expression quantitative trait locus rs6296 in the HTR1B gene is associated with susceptibility to opioid use disorder.
Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation.
Title: Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation.
First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development.
Title: First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development.
Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders.
Title: Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders.
Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.
Title: Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.

Submit: New GeneRIF Correction See all GeneRIFs (116)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HTR1B_992 (e-PCR)
- UniSTS:277337

HTR1B_V264 (e-PCR)
- UniSTS:277337

GDB:580593 (e-PCR)
- UniSTS:157835

GDB:580596 (e-PCR)
- UniSTS:157836

GDB:580599 (e-PCR)
- UniSTS:157837

GDB:580603 (e-PCR)
- UniSTS:157838

GDB:580608 (e-PCR)
- UniSTS:157839

GDB:580611 (e-PCR)
- UniSTS:157840

RH47746 (e-PCR)
- UniSTS:53392

GDB:580614 (e-PCR)
- UniSTS:157841

GDB:580618 (e-PCR)
- UniSTS:157842

GDB:580621 (e-PCR)
- UniSTS:157843

NoName (e-PCR)
- UniSTS:481202

PMC311033P3 (e-PCR)
- UniSTS:272841

GDB:603580 (e-PCR)
- UniSTS:158176

GDB:603584 (e-PCR)
- UniSTS:158177

GDB:603594 (e-PCR)
- UniSTS:158178

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Gi/o-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Gi/o-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	IEA Inferred from Electronic Annotation more info
enables serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in bone remodeling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to alkaloid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of serotonin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to mineralocorticoid	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	IEA Inferred from Electronic Annotation more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in serotonergic synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1B

Names: 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; serotonin 1D beta receptor; serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000863.3 → NP_000854.1 5-hydroxytryptamine receptor 1B

See identical proteins and their annotated locations for NP_000854.1

Status: VALIDATED

Source sequence(s)

AL049595

Consensus CDS

CCDS4986.1

UniProtKB/Swiss-Prot

P28222, Q4VAY7

UniProtKB/TrEMBL

A8K215, X5D7I5

Related

ENSP00000358963.3, ENST00000369947.5

Conserved Domains (1) summary

cd15333
Location:46 → 380

7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors