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syvn1 synovial apoptosis inhibitor 1, synoviolin [ Danio rerio (zebrafish) ]

Gene ID: 335226, updated on 4-Jan-2025

Summary

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Official Symbol
syvn1provided by ZNC
Official Full Name
synovial apoptosis inhibitor 1, synoviolinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7166
See related
Ensembl:ENSDARG00000017842 AllianceGenome:ZFIN:ZDB-GENE-030131-7166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55735; zgc:77108; wu:fk91f10
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum quality control compartment. Is expressed in several structures, including axial mesoderm; floor plate; hatching gland; hypochord; and notochord. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See syvn1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (26452692..26465795, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (26154587..26167690, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene phospholipase D family, member 7 Neighboring gene G protein-coupled receptor 137 Neighboring gene SMAD family member 5 Neighboring gene transforming growth factor, beta-induced

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms. Tsuchiya Y, et al. Mol Cell Biol, 2011 Nov. PMID 21911472, Free PMC Article
  2. The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis. Hou N, et al. Dev Biol, 2017 Jan 1. PMID 27851892
  3. Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish. Christen V, et al. Toxicol Appl Pharmacol, 2013 Oct 15. PMID 23800688
  4. XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Hu MC, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17560942
  5. Indium and indium tin oxide induce endoplasmic reticulum stress and oxidative stress in zebrafish (Danio rerio). Brun NR, et al. Environ Sci Technol, 2014 Oct 7. PMID 25188630

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum quality control compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase synoviolin
Names
HRD1 protein
RING-type E3 ubiquitin transferase synoviolin
NP_997900.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212735.2 → NP_997900.2  E3 ubiquitin-protein ligase synoviolin

    Status: VALIDATED

    Source sequence(s)
    BX323077, EB951305, EH551324
    UniProtKB/Swiss-Prot
    Q6NYA5, Q803I8
    UniProtKB/TrEMBL
    A0A8N7V0A8, A5PMC1
    Related
    ENSDARP00000116575.1, ENSDART00000143454.3
    Conserved Domains (2) summary
    pfam13639
    Location:289 → 330
    zf-RING_2; Ring finger domain
    cl21590
    Location:21 → 256
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    26452692..26465795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803I8.2 GenPept UniProtKB/Swiss-Prot:Q803I8

Gene LinkOut

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