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toc toucan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33526, updated on 4-Jan-2025

Summary

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Official Symbol
tocprovided by FlyBase
Official Full Name
toucanprovided by FlyBase
Primary source
FLYBASE:FBgn0015600
Locus tag
Dmel_CG9660
See related
AllianceGenome:FB:FBgn0015600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BA34; BcDNA:LD27161; CG9660; Dmel\CG9660; EN2-11; l(2)01361; l(2)05527; l(2)k08224; l(2)K08224; Toc
Summary
Predicted to enable microtubule binding activity. Involved in syncytial blastoderm mitotic cell cycle. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear membrane. Is expressed in several structures, including amnioserosa anlage; anlage in statu nascendi; ganglia; gonad; and head epidermis primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See toc in Genome Data Viewer
Location:
23D1-23D2; 2-8 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3068345..3144786, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3068345..3144786, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 23D Neighboring gene Fatty acid synthase 2 Neighboring gene Fatty acid synthase 1 Neighboring gene Protein phosphatase D6 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 B subunit Neighboring gene Mothers against dpp

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability. Mirouse V, et al. Genes Cells, 2005 Jan. PMID 15670212
  2. Expression and cellular localization of the Toucan protein during Drosophila oogenesis. Grammont M, et al. Mech Dev, 2000 Feb. PMID 10640714
  3. minifly, a Drosophila gene required for ribosome biogenesis. Giordano E, et al. J Cell Biol, 1999 Mar 22. PMID 10087258, Free PMC Article
  4. Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. Kim-Ha J, et al. Mol Cell Biol, 1999 Apr. PMID 10082516, Free PMC Article
  5. Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster. Carreira VP, et al. PLoS One, 2016. PMID 27459710, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that Toucan is a microtubule-associated protein specifically required for the stability of spindle microtubules throughout mitosis.
    Title: The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability.
  2. Essential for the assembly of syncytial mitotic spindles in D. melanogaster embryo.
    Title: Toucan protein is essential for the assembly of syncytial mitotic spindles in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
toucan
Names
CG9660-PA
CG9660-PB
CG9660-PC
CG9660-PD
CG9660-PE
CG9660-PF
CG9660-PG
CG9660-PH
CG9660-PI
CG9660-PJ
enhancer of NA9 2-11
toc-PA
toc-PB
toc-PC
toc-PD
toc-PE
toc-PF
toc-PG
toc-PH
toc-PI
toc-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3068345..3144786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057805.3 → NP_477153.1  toucan, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46112, Q9VQM0
    Related
    FBpp0077346
    Conserved Domains (5) summary
    COG1340
    Location:1580 → 1850
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam04094
    Location:1302 → 1737
    DUF390; Protein of unknown function (DUF390)
    pfam11068
    Location:1642 → 1712
    YlqD; YlqD protein
    pfam16043
    Location:1652 → 1826
    DUF4795; Domain of unknown function (DUF4795)
    cl23720
    Location:1550 → 1668
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001273061.1 → NP_001259990.1  toucan, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PED5
    Conserved Domains (2) summary
    pfam09731
    Location:63 → 406
    Mitofilin; Mitochondrial inner membrane protein
    pfam12325
    Location:469 → 568
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

  3. NM_001042864.2 → NP_001036329.1  toucan, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8U3, Q8MRI5
    Conserved Domains (2) summary
    pfam12325
    Location:522 → 621
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl23720
    Location:333 → 451
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. NM_001273059.1 → NP_001259988.1  toucan, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259988.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCH2, Q8MRI5
    Conserved Domains (1) summary
    pfam12325
    Location:522 → 621
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

  5. NM_164526.2 → NP_722877.1  toucan, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQL8
    Related
    FBpp0077349
    Conserved Domains (1) summary
    pfam12325
    Location:570 → 669
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

  6. NM_001273058.1 → NP_001259987.1  toucan, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259987.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBW7
    Conserved Domains (1) summary
    pfam12325
    Location:417 → 516
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

  7. NM_001103594.2 → NP_001097064.1  toucan, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYU0, H1UUP1
    Conserved Domains (1) summary
    COG1196
    Location:71 → 397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. NM_001273060.1 → NP_001259989.1  toucan, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PC13, Q8MRI5
    Conserved Domains (3) summary
    pfam09731
    Location:111 → 450
    Mitofilin; Mitochondrial inner membrane protein
    pfam12325
    Location:513 → 612
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    cl23720
    Location:324 → 442
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  9. NM_164524.2 → NP_722875.2  toucan, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722875.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPZ2, Q8MRI5
    Related
    FBpp0077347
    Conserved Domains (2) summary
    pfam10473
    Location:500 → 643
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cl23720
    Location:372 → 490
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  10. NM_164525.2 → NP_722876.1  toucan, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPZ1
    Related
    FBpp0077348
    Conserved Domains (2) summary
    pfam09731
    Location:63 → 402
    Mitofilin; Mitochondrial inner membrane protein
    pfam12325
    Location:465 → 564
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYU0 A8DYU0
M9PBW7 M9PBW7
M9PC13 M9PC13
M9PCH2 M9PCH2
M9PED5 M9PED5
O46112 O46112
Q0E8U3 Q0E8U3
Q8IPZ1 Q8IPZ1
Q8IPZ2 Q8IPZ2
Q8MRI5 Q8MRI5
Q9VQL8 Q9VQL8
Q9VQM0 Q9VQM0

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