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HTR1E 5-hydroxytryptamine receptor 1E [ Homo sapiens (human) ]

Gene ID: 3354, updated on 27-Nov-2024

Summary

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Official Symbol
HTR1Eprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Eprovided by HGNC
Primary source
HGNC:HGNC:5291
See related
Ensembl:ENSG00000168830 MIM:182132; AllianceGenome:HGNC:5291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT1E
Summary
Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues See more
Orthologs
all
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Genomic context

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See HTR1E in Genome Data Viewer
Location:
6q14.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (86937528..87016679)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88146245..88225391)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87647246..87726397)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 643, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87291002-87292201 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:87307995-87308547 Neighboring gene MPRA-validated peak5941 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:87380117-87380640 Neighboring gene Sharpr-MPRA regulatory region 4618 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87433363-87434562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87440887-87441388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87441389-87441888 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:87497596-87498795 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607342-87607842 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607843-87608343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647030-87647585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647586-87648140 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:87679014-87680213 Neighboring gene ribosomal protein L7 pseudogene 29 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87748156-87748680 Neighboring gene small integral membrane protein 30-like Neighboring gene RN7SK pseudogene 209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. Zgombick JM, et al. Mol Pharmacol, 1992 Aug. PMID 1513320
  2. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Qin X, et al. Theranostics, 2021. PMID 34093864, Free PMC Article
  3. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. Levy FO, et al. FEBS Lett, 1992 Jan 20. PMID 1733778
  4. Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. Levy FO, et al. Genomics, 1994 Aug. PMID 8001977
  5. 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. Pierce PA, et al. Neuroscience, 1997 Dec. PMID 9316030

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel interaction between neurotrophic factor-alpha1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via beta-arrestin/ERK signaling.
    Title: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.
  2. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.
    Title: Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.
  3. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
  4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study of the serotoninergic system in migraine in the Spanish population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables Gi/o-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 1E
Names
5-HT-1E
5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
S31
serotonin receptor 1E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000865.3 → NP_000856.1  5-hydroxytryptamine receptor 1E

    See identical proteins and their annotated locations for NP_000856.1

    Status: VALIDATED

    Source sequence(s)
    AL157777, AL521170, BC069751, M91467
    Consensus CDS
    CCDS5006.1
    UniProtKB/Swiss-Prot
    E1P503, P28566, Q9P1Y1
    Related
    ENSP00000307766.4, ENST00000305344.7
    Conserved Domains (1) summary
    cd15335
    Location:23 → 355
    7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    86937528..87016679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535789.3 → XP_011534091.1  5-hydroxytryptamine receptor 1E isoform X1

    See identical proteins and their annotated locations for XP_011534091.1

    UniProtKB/Swiss-Prot
    E1P503, P28566, Q9P1Y1
    Conserved Domains (1) summary
    cd15335
    Location:23 → 355
    7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    88146245..88225391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355315.1 → XP_054211290.1  5-hydroxytryptamine receptor 1E isoform X1

    UniProtKB/Swiss-Prot
    E1P503, P28566, Q9P1Y1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28566.1 GenPept UniProtKB/Swiss-Prot:P28566

Gene LinkOut

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