U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snap25 Synaptosomal-associated protein 25kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355084, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Snap25provided by FlyBase
Official Full Name
Synaptosomal-associated protein 25kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0011288
Locus tag
Dmel_CG40452
See related
AllianceGenome:FB:FBgn0011288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17676; CG17884; CG40452; Dmel\CG40452; dSNAP-25; dSnap25; snap-25; SNAP-25; snap25; SNAP25; snp25
Summary
Enables SNAP receptor activity and SNARE binding activity. Involved in chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and synaptic vesicle transport. Located in terminal bouton. Part of SNARE complex. Is expressed in several structures, including abdominal neuromere; adult brain; adult head; adult optic lobe; and ganglia. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to several human genes including SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Snap25 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24074180..24299205)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24067280..24292305)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40053 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45159 Neighboring gene neverland Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones. Risinger C, et al. J Biol Chem, 1993 Nov 15. PMID 8226991
  2. Complex gene organization of synaptic protein SNAP-25 in Drosophila melanogaster. Risinger C, et al. Gene, 1997 Jul 31. PMID 9272858
  3. Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis. Washbourne P, et al. FEBS Lett, 1997 Nov 24. PMID 9414082
  4. Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. Rao SS, et al. EMBO J, 2001 Dec 3. PMID 11726512, Free PMC Article
  5. Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction. Megighian A, et al. J Cell Sci, 2010 Oct 1. PMID 20826463

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results indicate that SNAP-25-R206 and syntaxin-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE complexes interacting via the ionic couple formed by these two residues.
    Title: Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.
  2. Results establish in vivo contributions of SNAP-25 and NSF to synaptic vesicle trafficking and define molecular mechanisms determining conserved functional properties of short-term depression.
    Title: Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants.
  3. study found dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 and cysteine string protein
    Title: Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
  4. reveals context-dependent redundancy with SNAP-24 in neurotransmission
    Title: A Drosophila SNAP-25 null mutant reveals context-dependent redundancy with SNAP-24 in neurotransmission.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 24272148-24279757 mobile_element_type = transposon:opus{}6618
  • Loc: 24280512-24281594 mobile_element_type = transposon:1360{}6361
  • Loc: 24292035-24293047 mobile_element_type = transposon:1360{}6363

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle docking NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle priming IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Synaptosomal-associated protein 25kDa
Names
CG40452-PA
CG40452-PC
Snap25-PA
Snap25-PC
synapse protein 25
synaptosomal-associated protein 25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    24074180..24299205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043176.2 → NP_001036641.1  Synaptosomal-associated protein 25kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036641.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F3YD56, P36975, Q5LJU6, Q7PLV2
    Conserved Domains (3) summary
    cd15885
    Location:151 → 209
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15889
    Location:28 → 87
    SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
    pfam00835
    Location:98 → 149
    SNAP-25; SNAP-25 family

  2. NM_001043177.3 → NP_001036642.2  Synaptosomal-associated protein 25kDa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036642.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36975
    Conserved Domains (3) summary
    cd15885
    Location:151 → 209
    SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
    cd15889
    Location:28 → 87
    SNARE_SNAP25N_23N; N-terminal SNARE motif of SNAP25 and SNAP23
    pfam00835
    Location:98 → 149
    SNAP-25; SNAP-25 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36975.1 P36975

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous