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Slmap Sarcolemma associated protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355127, updated on 9-Dec-2024

Summary

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Official Symbol
Slmapprovided by FlyBase
Official Full Name
Sarcolemma associated proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0040011
Locus tag
Dmel_CG17494
See related
AllianceGenome:FB:FBgn0040011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17494; Dmel\CG17494; slmap; SLMAP
Summary
Enables protein kinase binding activity. Involved in negative regulation of hippo signaling and negative regulation of peptidoglycan recognition protein signaling pathway. Part of FAR/SIN/STRIPAK complex. Is expressed in adult head and organism. Orthologous to several human genes including SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Slmap in Genome Data Viewer
Location:
40F7-40F7; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22579072..22585843)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22471804..22478575)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43927 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster. Mao B, et al. Insect Sci, 2022 Dec. PMID 35271765
  2. STRIPAK complexes: structure, biological function, and involvement in human diseases. Hwang J, et al. Int J Biochem Cell Biol, 2014 Feb. PMID 24333164, Free PMC Article
  3. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Zheng Y, et al. Cell Rep, 2017 Dec 19. PMID 29262338, Free PMC Article
  4. The SILAC fly allows for accurate protein quantification in vivo. Sury MD, et al. Mol Cell Proteomics, 2010 Oct. PMID 20525996, Free PMC Article
  5. A conserved STRIPAK complex is required for autophagy in muscle tissue. Guo Y, et al. Mol Biol Cell, 2023 Aug 1. PMID 37379167, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction HGI PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sarcolemma associated protein
Names
CG17494-PA
CG17494-PD
Slmap-PA
Slmap-PD
sarcolemma associated protein ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    22579072..22585843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042934.2 → NP_001036399.1  sarcolemma associated protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH6, Q0E8L9, Q9W5R5
    Conserved Domains (2) summary
    COG1716
    Location:225 → 326
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:216 → 311
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

  2. NM_001042932.2 → NP_001036397.2  sarcolemma associated protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036397.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH6, Q0E8L9, Q9W5R5
    Conserved Domains (2) summary
    COG1716
    Location:225 → 326
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:216 → 311
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W5R5 Q9W5R5

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