U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG42346 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355160, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG42346provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259677
Locus tag
Dmel_CG42346
See related
AllianceGenome:FB:FBgn0259677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40500; CG40500-PA; CG41105; Dmel\CG42346
Old locus tag
Dmel_CG40500; Dmel_CG41105
Summary
Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; and primary immunodeficiency disease (multiple). Orthologous to several human genes including IGFALS (insulin like growth factor binding protein acid labile subunit); NRROS (negative regulator of reactive oxygen species); and TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG42346 in Genome Data Viewer
Location:
20E2-20F1; 1-66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22832399..22885541)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22234235..22287377)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45464 Neighboring gene uncharacterized protein Neighboring gene mir-2491 stem loop Neighboring gene folded gastrulation Neighboring gene long non-coding RNA:CR43656 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR41352 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Bergman CM, et al. Genome Biol, 2006. PMID 17134480, Free PMC Article
  2. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Swanson LE, et al. Genetics, 2009 Apr. PMID 19171940, Free PMC Article
  3. Genome ARTIST_v2-An Autonomous Bioinformatics Tool for Annotation of Natural Transposons in Sequenced Genomes. Ecovoiu AA, et al. Int J Mol Sci, 2022 Oct 21. PMID 36293549, Free PMC Article
  4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
  5. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 22838038-22838552 mobile_element_type = transposon:INE-1{}3613
  • Loc: 22841928-22843500 mobile_element_type = transposon:HB{}276
  • Loc: 22875600-22875928 mobile_element_type = transposon:INE-1{}3787
  • Loc: 22882039-22883543 mobile_element_type = transposon:HB{}4413

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG42346-PC
CG42346-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    22832399..22885541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042838.2 → NP_001036303.2  uncharacterized protein Dmel_CG42346, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036303.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHN6
    Conserved Domains (4) summary
    cd00116
    Location:804 → 1076
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:725 → 736
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:534 → 556
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1163 → 1219
    LRR_8; Leucine rich repeat

  2. NM_001042841.4 → NP_001036306.3  uncharacterized protein Dmel_CG42346, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036306.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHN6
    Conserved Domains (4) summary
    cd00116
    Location:804 → 1076
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:725 → 736
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:534 → 556
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:1163 → 1219
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KHN6 Q0KHN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools