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CG2772 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33559, updated on 9-Dec-2024

Summary

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Official Symbol
CG2772provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031533
Locus tag
Dmel_CG2772
See related
AllianceGenome:FB:FBgn0031533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE45077; Dmel\CG2772
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG2772 in Genome Data Viewer
Location:
23F3-23F3; 2-10 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3445992..3447589)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3445992..3447589)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 1 Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. Hundertmark T, et al. PLoS One, 2019. PMID 30845228, Free PMC Article
  2. Control of lipid metabolism by tachykinin in Drosophila. Song W, et al. Cell Rep, 2014 Oct 9. PMID 25263556, Free PMC Article
  3. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article
  4. Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. Fleck SA, et al. Elife, 2024 Jan 19. PMID 38240746, Free PMC Article
  5. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2772-PA
NP_608776.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3445992..3447589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134932.3 → NP_608776.1  uncharacterized protein Dmel_CG2772 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQQ5
    Related
    FBpp0077205
    Conserved Domains (3) summary
    PLN02872
    Location:5 → 393
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:36 → 103
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    cl21494
    Location:113 → 196
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQQ5 Q9VQQ5

Gene LinkOut

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