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Pif1 Pif1 DNA helicase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33567, updated on 9-Dec-2024

Summary

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Official Symbol
Pif1provided by FlyBase
Official Full Name
Pif1 DNA helicaseprovided by FlyBase
Primary source
FLYBASE:FBgn0031540
Locus tag
Dmel_CG3238
See related
AllianceGenome:FB:FBgn0031540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3238; Dmel\CG3238; pif1
Summary
Predicted to enable 5'-3' DNA helicase activity. Involved in double-strand break repair via break-induced replication. Predicted to be active in replication fork. Is expressed in organism. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Pif1 in Genome Data Viewer
Location:
23F3-23F3; 2-10 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3467342..3470004, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3467342..3470004, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene male-specific lethal 2 Neighboring gene mir-4971 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) PDSW subunit Neighboring gene uncharacterized protein Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Homolog-Dependent Repair Following Dicentric Chromosome Breakage in Drosophila melanogaster. Bhandari J, et al. Genetics, 2019 Jul. PMID 31053594, Free PMC Article
  2. Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells. Al Zouabi L, et al. Cell Rep, 2023 Dec 26. PMID 38032794
  3. The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair. Kocak E, et al. Genetics, 2019 Nov. PMID 31537623, Free PMC Article
  4. Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA. Ciesielski GL, et al. J Biol Chem, 2015 Nov 27. PMID 26446790, Free PMC Article
  5. Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells. Alexander JL, et al. Proc Natl Acad Sci U S A, 2016 Nov 29. PMID 27849606, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila PIF1 functions with POL32 during times of replication stress but acts independently of POL32 to promote synthesis during double-strand gap repair.
    Title: The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Pif1 DNA helicase
Names
CG3238-PA
CG3238-PB
Pif1 helicase
Pif1 ortholog
Pif1-PA
Pif1-PB
NP_001285587.1
NP_608782.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3467342..3470004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298658.1 → NP_001285587.1  Pif1 DNA helicase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQR3
    Conserved Domains (1) summary
    cl21455
    Location:205 → 510
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_134938.3 → NP_608782.1  Pif1 DNA helicase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQR3
    Related
    FBpp0077258
    Conserved Domains (1) summary
    cl21455
    Location:205 → 510
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQR3 Q9VQR3

Gene LinkOut

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