IFT57 Intraflagellar transport 57 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: IFT57provided by FlyBase
Official Full Name: Intraflagellar transport 57provided by FlyBase
Primary source: FLYBASE:FBgn0031550
Locus tag: Dmel_CG8853
See related: AllianceGenome:FB:FBgn0031550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8853; che-13; Che-13; CHE-13; Dmel\CG8853; Hippi; IFT55
Summary: Predicted to be involved in several processes, including apoptotic process; cilium organization; and positive regulation of cysteine-type endopeptidase activity. Predicted to be located in ciliary basal body. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi apparatus; cilium; and microtubule organizing center. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XVIII. Orthologous to human IFT57 (intraflagellar transport 57). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3530789..3532678)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3530789..3532678)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain