odd odd skipped [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: oddprovided by FlyBase
Official Full Name: odd skippedprovided by FlyBase
Primary source: FLYBASE:FBgn0002985
Locus tag: Dmel_CG3851
See related: AllianceGenome:FB:FBgn0002985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3851; Dmel\CG3851; l(2)01863; Odd; ODD; ods
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Malpighian tubule morphogenesis; regulation of transcription by RNA polymerase II; and segmentation. Predicted to be active in nucleus. Is expressed in several structures, including dMP2 neuron; gut section; head epidermis primordium; nephrocyte; and somatic precursor cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 24A1-24A1; 2-10 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3604224..3606756, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3604224..3606756, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provided evidence that the Odd neurons are a hemilineage, suggesting they are born from a defined set of neuroblasts.
Title: Odd-skipped labels a group of distinct neurons associated with the mushroom body and optic lobe in the adult Drosophila brain.
The odd-skipped genes act at the anterior notum border to organize the notum anterior-posterior (AP) axis using both autonomous and non-autonomous mechanisms.
Title: odd-skipped genes and lines organize the notum anterior-posterior axis using autonomous and non-autonomous mechanisms.
Decapentaplegic signaling limits Odd-skipped expression to promote prohemocyte differentiation.
Title: Odd-skipped maintains prohemocyte potency and blocks blood cell development in Drosophila.
Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs
Title: Odd-skipped genes encode repressors that control kidney development.
Protein Odd-skipped, requires its eh1-like sequence to bind Groucho for repressing specific target genes in segmentation.
Title: An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hindgut morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning by pair rule gene	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: odd skipped

Names: CG3851-PA; odd paired; odd-PA; odd-skipped; oddskipped

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3604224..3606756 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164546.2 → NP_722922.1 odd skipped [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23803, Q9VQS9

Related

FBpp0077246

Conserved Domains (4) summary

COG5048
Location:203 → 334

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:222 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:304 → 326

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:234 → 259

zf-H2C2_2; Zinc-finger double domain