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emsy EMSY transcriptional repressor, BRCA2 interacting [ Danio rerio (zebrafish) ]

Gene ID: 335889, updated on 4-Jan-2025

Summary

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Official Symbol
emsyprovided by ZNC
Official Full Name
EMSY transcriptional repressor, BRCA2 interactingprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7832
See related
Ensembl:ENSDARG00000059059 AllianceGenome:ZFIN:ZDB-GENE-030131-7832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj36b04; zgc:56039; wu:fj36b04
Summary
Predicted to act upstream of or within DNA repair; chromatin organization; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See emsy in Genome Data Viewer
Location:
chromosome: 10
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (282770..302831, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (284186..302919, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene kelch-like family member 35 Neighboring gene leucine rich repeat containing 32 Neighboring gene wu:fj39h09 Neighboring gene v-akt murine thymoma viral oncogene homolog 2, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BRCA2-interacting transcriptional repressor EMSY
Names
EMSY BRCA2-interacting transcriptional repressor
protein EMSY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199984.2 → NP_956278.2  BRCA2-interacting transcriptional repressor EMSY

    Status: VALIDATED

    Source sequence(s)
    CABZ01049608, CU469093
    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    B2GRX8
    Related
    ENSDARP00000138672.2, ENSDART00000157582.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    282770..302831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305037.4 → XP_009303312.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    See identical proteins and their annotated locations for XP_009303312.1

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3B5X7, B2GRX8
    Conserved Domains (1) summary
    pfam03735
    Location:30 → 96
    ENT; ENT domain

  2. XM_009305041.4 → XP_009303316.1  BRCA2-interacting transcriptional repressor EMSY isoform X5

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3AWD8, B2GRX8
    Conserved Domains (1) summary
    pfam03735
    Location:30 → 96
    ENT; ENT domain

  3. XM_068223730.1 → XP_068079831.1  BRCA2-interacting transcriptional repressor EMSY isoform X4

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    B2GRX8

  4. XM_009305040.4 → XP_009303315.1  BRCA2-interacting transcriptional repressor EMSY isoform X3

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3BCQ8, B2GRX8
    Conserved Domains (2) summary
    pfam03735
    Location:30 → 96
    ENT; ENT domain
    pfam05109
    Location:300 → 759
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. XM_009305039.4 → XP_009303314.1  BRCA2-interacting transcriptional repressor EMSY isoform X2

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3AWE9, B2GRX8
    Conserved Domains (1) summary
    pfam03735
    Location:30 → 96
    ENT; ENT domain

  6. XM_009305036.4 → XP_009303311.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    See identical proteins and their annotated locations for XP_009303311.1

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3B5X7, B2GRX8
    Conserved Domains (1) summary
    pfam03735
    Location:30 → 96
    ENT; ENT domain

  7. XM_068223729.1 → XP_068079830.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    UniProtKB/Swiss-Prot
    Q7ZUV7
    UniProtKB/TrEMBL
    A0A8M3B5X7, B2GRX8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZUV7.1 GenPept UniProtKB/Swiss-Prot:Q7ZUV7

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