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IM33 Immune induced molecule 33 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33592, updated on 4-Jan-2025

Summary

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Official Symbol
IM33provided by FlyBase
Official Full Name
Immune induced molecule 33provided by FlyBase
Primary source
FLYBASE:FBgn0031561
Locus tag
Dmel_CG16712
See related
AllianceGenome:FB:FBgn0031561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH05411; BcDNA:RH38008; CG16712; CT37183; DIM 33; Dmel\CG16712
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in response to bacterium. Predicted to be active in extracellular space. Is expressed in embryonic hindgut; embryonic large intestine; and embryonic/larval fat body. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See IM33 in Genome Data Viewer
Location:
24B3-24B3; 2-10 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3696218..3696658, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3696218..3696658, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recurrent evolution of high virulence in isolated populations of a DNA virus. Hill T, et al. Elife, 2020 Oct 28. PMID 33112738, Free PMC Article
  2. A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan. Xu W, et al. Neuron, 2023 Oct 18. PMID 37582366, Free PMC Article
  3. A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation. Regadas I, et al. Mol Cell, 2021 Apr 15. PMID 33631105
  4. Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. Goodliffe JM, et al. BMC Mol Biol, 2007 May 22. PMID 17519021, Free PMC Article
  5. Peptidomic and proteomic analyses of the systemic immune response of Drosophila. Levy F, et al. Biochimie, 2004 Sep-Oct. PMID 15556270

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan.
    Title: A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to bacterium HEP PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
immune induced molecule 33
Names
CG16712-PA
CG16712-PB
IM33-PA
IM33-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3696218..3696658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298665.1 → NP_001285594.1  immune induced molecule 33, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQT8
    Conserved Domains (1) summary
    cd00109
    Location:23 → 81
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  2. NM_134956.4 → NP_608800.1  immune induced molecule 33, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQT8
    Related
    FBpp0077235
    Conserved Domains (1) summary
    cd00109
    Location:23 → 81
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQT8 Q9VQT8

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