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il12bb interleukin 12B, b [ Danio rerio (zebrafish) ]

Gene ID: 335994, updated on 4-Jan-2025

Summary

Official Symbol
il12bbprovided by ZNC
Official Full Name
interleukin 12B, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7937
See related
Ensembl:ENSDARG00000054542 AllianceGenome:ZFIN:ZDB-GENE-030131-7937
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
il-12p40.a
Summary
Predicted to enable cytokine activity. Predicted to be located in extracellular space. Is expressed in digestive system; gill; immune system; and muscle. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See il12bb in Genome Data Viewer
Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (35291592..35302192)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805539.1 (18874..22020, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488838 Neighboring gene ubiquitin domain containing 2 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene arginyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin 12B, b; interleukin-12 subunit beta
Names
interleukin 12 receptor p40.a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    35291592..35302192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216128.1XP_068072229.1  interleukin-12 subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8M9PV11
    Related
    ENSDARP00000129182.2, ENSDART00000155140.3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395096.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    278535..284174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218978.1XP_068075079.1  interleukin-12 subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q7B2