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trr1 thioredoxin reductase Trr1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 3361358, updated on 18-Sep-2024

Summary

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Official Symbol
trr1
Official Full Name
thioredoxin reductase Trr1
Primary source
PomBase:SPBC3F6.03
Locus tag
SPOM_SPBC3F6.03
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
caf4; trxR
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Genomic context

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See trr1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (4189799..4191448)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 3 beta-hydroxysteroid dehydrogenase/delta 5-to-4-isomerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP protein Nop14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast. Hong SM, et al. FEMS Microbiol Lett, 2004 May 15. PMID 15135546
  2. Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase. Boronat S, et al. PLoS Genet, 2017 Jun. PMID 28640807, Free PMC Article
  3. Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach. García-Santamarina S, et al. Antioxid Redox Signal, 2013 May 1. PMID 23121505, Free PMC Article
  4. The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Jara M, et al. Mol Biol Cell, 2007 Jun. PMID 17409354, Free PMC Article
  5. A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein. Brown JD, et al. Cell Rep, 2013 Dec 12. PMID 24268782, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
thioredoxin reductase Trr1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4189799..4191448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022668.3 → NP_001018848.1  thioredoxin reductase Trr1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_001018848.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q92375
    Conserved Domains (3) summary
    TIGR01292
    Location:5 → 315
    TRX_reduct; thioredoxin-disulfide reductase
    pfam00070
    Location:157 → 221
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    cl21454
    Location:6 → 124
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version

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