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bdl borderless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33635, updated on 4-Jan-2025

Summary

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Official Symbol
bdlprovided by FlyBase
Official Full Name
borderlessprovided by FlyBase
Primary source
FLYBASE:FBgn0028482
Locus tag
Dmel_CG16857
See related
AllianceGenome:FB:FBgn0028482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH11322; CG16857; CT35491; Dmel\CG16857; GH11322
Summary
Enables cell-cell adhesion mediator activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; nervous system development; and neuron cell-cell adhesion. Located in plasma membrane. Is expressed in several structures, including adult head; adult optic lobe; glial cell; medulla layer; and synaptic neuropil domain. Orthologous to human IGSF9 (immunoglobulin superfamily member 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See bdl in Genome Data Viewer
Location:
24E1-24E1; 2-12 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4324554..4331830)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4324554..4331830)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Arginine methyltransferase 2 Neighboring gene turtle Neighboring gene ABC transporter expressed in trachea Neighboring gene long non-coding RNA:CR44697 Neighboring gene mir-1005 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Turtle interacts with borderless in regulating glial extension and axon ensheathment. Chen Y, et al. Mol Brain, 2017 May 23. PMID 28535795, Free PMC Article
  2. The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision in Drosophila. Shaw HS, et al. J Neurosci, 2019 Aug 28. PMID 31235647, Free PMC Article
  3. Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila. Chang YC, et al. Sci Rep, 2018 Aug 23. PMID 30140062, Free PMC Article
  4. Borderless regulates glial extension and axon ensheathment. Cameron S, et al. Dev Biol, 2016 Jun 15. PMID 27131624
  5. Control of directional change after mechanical stimulation in Drosophila. Zhou Y, et al. Mol Brain, 2012 Oct 29. PMID 23107101, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. bdl plays a novel and specific role in regulating axonal transport of SV components. Loss of bdl disrupts axonal transport of SV components in photoreceptor R8 axons, but does not affect the transport of mitochondria. Genetic mosaic analysis, transgene rescue and cell-type-specific knockdown indicate that Bdl is required both presynaptically and postsynaptically for delivering SV components in R8 axons
    Title: The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision in Drosophila.
  2. Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.
    Title: Turtle interacts with borderless in regulating glial extension and axon ensheathment.
  3. Bdl is expressed in wrapping glia (WG) in the developing eye disc. Bdl is specifically required in WG for the extension of glial processes along photoreceptor axons in the optic lobe, and axon ensheathment.
    Title: Borderless regulates glial extension and axon ensheathment.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell-cell adhesion mediator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in R7 cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in R7 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon ensheathment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glial cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
borderless
Names
CG16857-PA
bdl-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4324554..4331830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134978.3 → NP_608822.1  borderless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0PTX2, Q95U86, Q9U4G1, Q9VQY3
    Related
    FBpp0077115
    Conserved Domains (6) summary
    smart00408
    Location:356 → 419
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:260 → 327
    IG_like; Immunoglobulin like
    cd00063
    Location:435 → 524
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:153 → 242
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:252 → 337
    Ig_2; Immunoglobulin domain
    cl11960
    Location:157 → 242
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U4G1.1 Q9U4G1

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