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col1a2 collagen, type I, alpha 2 [ Danio rerio (zebrafish) ]

Gene ID: 336471, updated on 4-Jan-2025

Summary

Official Symbol
col1a2provided by ZNC
Official Full Name
collagen, type I, alpha 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8415
See related
Ensembl:ENSDARG00000020007 AllianceGenome:ZFIN:ZDB-GENE-030131-8415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zehn2357; alpha2(I); wu:fa98d05; wu:fa99g10; wu:fb04c08; wu:fb11d06; hm:zehn2357
Summary
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within response to mechanical stimulus and skeletal system development. Predicted to be located in extracellular region. Predicted to be part of collagen type I trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cranium; dermomyotome; integument; muscle; and pectoral fin. Used to study Ehlers-Danlos syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome (multiple); heart valve disease; intracranial aneurysm; osteogenesis imperfecta (multiple); and osteoporosis. Orthologous to human COL1A2 (collagen type I alpha 2 chain). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See col1a2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (40983221..41002336)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (41396092..41415219)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488548 Neighboring gene Bet1 golgi vesicular membrane trafficking protein Neighboring gene CAS1 domain containing 1 Neighboring gene sarcoglycan, epsilon Neighboring gene protein phosphatase 1, regulatory subunit 9A

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
part_of collagen trimer  
part_of collagen type I trimer  
is_active_in collagen-containing extracellular matrix  
located_in extracellular region  
is_active_in extracellular space  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182968.2 → NP_892013.2  collagen alpha-2(I) chain precursor

    See identical proteins and their annotated locations for NP_892013.2

    Status: PROVISIONAL

    Source sequence(s)
    BC071278
    UniProtKB/TrEMBL
    A0A8M1P8M3, Q1LW91, Q6IQX2
    Related
    ENSDARP00000118091.1, ENSDART00000144544.3
    Conserved Domains (2) summary
    pfam01391
    Location:936 → 995
    Collagen; Collagen triple helix repeat (20 copies)
    pfam01410
    Location:1120 → 1351
    COLFI; Fibrillar collagen C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    40983221..41002336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215040.1 → XP_068071141.1  collagen alpha-2(I) chain isoform X1

    UniProtKB/TrEMBL
    A0A8M1P8M3, Q1LW91, Q6IQX2
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