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Paris Parkin Interacting Substrate [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33657, updated on 9-Dec-2024

Summary

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Official Symbol
Parisprovided by FlyBase
Official Full Name
Parkin Interacting Substrateprovided by FlyBase
Primary source
FLYBASE:FBgn0031610
Locus tag
Dmel_CG15436
See related
AllianceGenome:FB:FBgn0031610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15436; Dmel\CG15436; dPARIS
Summary
Enables DNA binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of mitochondrial fission. Predicted to be located in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Paris in Genome Data Viewer
Location:
24F3-24F4; 2-12 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4463611..4465075)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4463611..4465075)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene uncharacterized protein Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene inebriated Neighboring gene dumpy Neighboring gene Heterochromatin protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying potential PARIS homologs in D. melanogaster. Merzetti EM, et al. Genet Mol Res, 2016 Nov 3. PMID 27819722
  2. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Pirooznia SK, et al. Mol Neurodegener, 2020 Mar 5. PMID 32138754, Free PMC Article
  3. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
  4. A small genomic region containing several loci required for gastrulation in Drosophila. Mathew SJ, et al. PLoS One, 2009 Oct 13. PMID 19823683, Free PMC Article
  5. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
parkin interacting substrate
Names
CG15436-PA
Paris-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4463611..4465075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134996.4 → NP_608840.1  parkin interacting substrate [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608840.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960V8, Q9VR05
    Related
    FBpp0077132
    Conserved Domains (4) summary
    COG5048
    Location:180 → 341
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:4 → 78
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:197 → 219
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VR05.2 Q9VR05

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