FIG4 FIG4 phosphoinositide 5-phosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FIG4provided by FlyBase
Official Full Name: FIG4 phosphoinositide 5-phosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0031611
Locus tag: Dmel_CG17840
See related: AllianceGenome:FB:FBgn0031611
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17840; dFIG 4; dFig4; dFIG4; Dmel\CG17840; Fig4
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity. Involved in regulation of lysosome organization. Predicted to be located in endosome membrane. Predicted to be part of PAS complex. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in organism. Used to study Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 4J; amyotrophic lateral sclerosis type 11; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4465174..4468022)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4465174..4468022)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Identification of Rpd3 as a novel epigenetic regulator of Drosophila FIG 4, a Charcot-Marie-Tooth disease-causing gene.
Title: Identification of Rpd3 as a novel epigenetic regulator of Drosophila FIG 4, a Charcot-Marie-Tooth disease-causing gene.
This study, using this CMT model fly, we carried out modifier screening to identify candidate genes which genetically interact with dFIG4.
Title: Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol bisphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PAS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

NP_608841.1

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The following sections contain reference sequences that belong to a specific genome build. Explain