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ine inebriated [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33659, updated on 4-Jan-2025

Summary

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Official Symbol
ineprovided by FlyBase
Official Full Name
inebriatedprovided by FlyBase
Primary source
FLYBASE:FBgn0011603
Locus tag
Dmel_CG15444
See related
AllianceGenome:FB:FBgn0011603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15444; CG15444d; Dmel\CG15444; DMINE; ine/rosA; rosA
Summary
Enables osmosensor activity. Involved in several processes, including multicellular organismal-level water homeostasis; perineurial glial growth; and transmission of nerve impulse. Located in basolateral plasma membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval midgut primordium; gut section; head; and ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ine in Genome Data Viewer
Location:
24F4-24F4; 2-12 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4468000..4477022, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4468000..4477022, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Parkin Interacting Substrate Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene dumpy Neighboring gene long non-coding RNA:CR43716 Neighboring gene Heterochromatin protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A neurotransmitter transporter encoded by the Drosophila inebriated gene. Soehnge H, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917579, Free PMC Article
  2. The putative Na⁺/Cl⁻-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis. Luan Z, et al. Sci Rep, 2015 Jan 23. PMID 25613130, Free PMC Article
  3. Location and functions of Inebriated in the Drosophila eye. Borycz J, et al. Biol Open, 2018 Jul 23. PMID 30037884, Free PMC Article
  4. The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling. Chiu C, et al. J Exp Biol, 2000 Dec. PMID 11060215
  5. In vivo properties of the Drosophila inebriated-encoded neurotransmitter transporter. Huang Y, et al. J Neurosci, 2002 Mar 1. PMID 11880499, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. two protein isoforms encoded by the inebriated (ine) gene perform osmolyte transport within the Malpighian tubule and hindgut
    Title: The Drosophila inebriated-encoded neurotransmitter/osmolyte transporter: dual roles in the control of neuronal excitability and the osmotic stress response.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables amino acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotransmitter:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter:sodium symporter activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables neurotransmitter:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables osmosensor activity IEA
Inferred from Electronic Annotation
more info
  
enables osmosensor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glial cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter transport ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in perineurial glial growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
  
involved_in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
inebriated
Names
CG15444-PA
CG15444-PB
CG15444-PC
CG15444-PE
CG15444-PF
ine-PA
ine-PB
ine-PC
ine-PE
ine-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4468000..4477022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175958.3 → NP_787972.1  inebriated, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787972.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V056, O02003, Q94917, Q9VR07
    UniProtKB/TrEMBL
    E1JHT2
    Related
    FBpp0077138
    Conserved Domains (1) summary
    cl00456
    Location:337 → 876
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_057664.6 → NP_477012.1  inebriated, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477012.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V056, O02003, Q94917, Q9VR07
    UniProtKB/TrEMBL
    E1JHT2
    Related
    FBpp0077136
    Conserved Domains (1) summary
    cl00456
    Location:337 → 876
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_057665.5 → NP_477013.1  inebriated, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477013.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV47
    Related
    FBpp0077137
    Conserved Domains (1) summary
    cl00456
    Location:52 → 591
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001169400.2 → NP_001162871.1  inebriated, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162871.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V056, O02003, Q94917, Q9VR07
    UniProtKB/TrEMBL
    E1JHT2
    Conserved Domains (1) summary
    cl00456
    Location:337 → 876
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_175959.3 → NP_787973.1  inebriated, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787973.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V056, O02003, Q94917, Q9VR07
    UniProtKB/TrEMBL
    E1JHT2
    Related
    FBpp0290621
    Conserved Domains (1) summary
    cl00456
    Location:337 → 876
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHT2 E1JHT2
Q9VR07.1 Q9VR07

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