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CG3251 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33671, updated on 9-Dec-2024

Summary

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Official Symbol
CG3251provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031622
Locus tag
Dmel_CG3251
See related
AllianceGenome:FB:FBgn0031622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3251
Summary
Predicted to enable deubiquitinase activity and serine-type peptidase activity. Involved in regulation of apoptotic process. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to several human genes including OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG3251 in Genome Data Viewer
Location:
25A3-25A3; 2-13 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4688965..4690702, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4688965..4690702, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Early boundary activity 1 Neighboring gene Early boundary activity 3 Neighboring gene decima Neighboring gene TBP-associated factor 30kD subunit alpha-2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. Louis M, et al. PLoS One, 2015. PMID 26588485, Free PMC Article
  2. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
  3. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article
  4. Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster. Páhi ZG, et al. Sci Rep, 2022 Apr 7. PMID 35393473, Free PMC Article
  5. A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. Zhang J, et al. G3 (Bethesda), 2012 Dec. PMID 23275879, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3251-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4688965..4690702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135007.2 → NP_608851.1  uncharacterized protein Dmel_CG3251 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VR20
    Related
    FBpp0077113
    Conserved Domains (1) summary
    cl19932
    Location:36 → 115
    OTU; OTU-like cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VR20 Q9VR20

Gene LinkOut

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