smog smog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: smogprovided by FlyBase
Official Full Name: smogprovided by FlyBase
Primary source: FLYBASE:FBgn0051660
Locus tag: Dmel_CG31660
See related: AllianceGenome:FB:FBgn0051660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.181; anon-WO0170980.182; CG11923; CG11925; CG31660; Dmel\CG31660; pog; Smog
Summary: Enables G protein-coupled receptor activity. Involved in several processes, including gastrulation; mesectoderm development; and positive regulation of antibacterial peptide biosynthetic process. Is active in plasma membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 25B1-25B1; 2-14 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4852864..4876792)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4852864..4876792)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
Title: FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
The G protein-coupled receptor Smog activity is concentrated on two different apical plasma membrane compartments, i.e., the surface and plasma membrane invaginations.
Title: Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in apical constriction involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cytoskeleton polarity involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: smog

Names: CG31660-PB; CG31660-PC; CG31660-PD; CG31660-PE; CG31660-PF; poor gastrulation; smog-PB; smog-PC; smog-PD; smog-PE; smog-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4852864..4876792

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273127.1 → NP_001260056.1 smog, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260056.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEK9

Conserved Domains (1) summary

pfam00003
Location:542 → 776

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
NM_001258953.2 → NP_001245882.1 smog, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245882.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDF0

Conserved Domains (1) summary

pfam00003
Location:542 → 776

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
NM_001258952.2 → NP_001245881.1 smog, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245881.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND25

Conserved Domains (1) summary

pfam00003
Location:542 → 776

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
NM_164600.4 → NP_723019.2 smog, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723019.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VR40

Conserved Domains (1) summary

pfam00003
Location:542 → 776

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
NM_001014465.3 → NP_001014465.1 smog, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014465.1

Status: REVIEWED

UniProtKB/TrEMBL

Q59E18

Conserved Domains (1) summary

pfam00003
Location:542 → 776

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR