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Marcal1 Marcal1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33709, updated on 9-Dec-2024

Summary

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Official Symbol
Marcal1provided by FlyBase
Official Full Name
Marcal1provided by FlyBase
Primary source
FLYBASE:FBgn0031655
Locus tag
Dmel_CG3753
See related
AllianceGenome:FB:FBgn0031655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3753; Dmel\CG3753; dmHARP; HARP; Marca1; MARCAL1
Summary
Enables ATP-dependent DNA/DNA annealing activity and four-way junction helicase activity. Involved in DNA rewinding and heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing. Located in nucleus and polytene chromosome interband. Used to study Schimke immuno-osseous dysplasia. Human ortholog(s) of this gene implicated in Schimke immuno-osseous dysplasia. Orthologous to human SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Marcal1 in Genome Data Viewer
Location:
25B4-25B4; 2-14 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4955509..4958292)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4955509..4958292)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jonah 25Bii Neighboring gene Jonah 25Bi Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43824 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit i

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The annealing helicase and branch migration activities of Drosophila HARP. Kassavetis GA, et al. PLoS One, 2014. PMID 24866343, Free PMC Article
  2. The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila. Dewey EB, et al. Genetics, 2023 Jan 12. PMID 36303322, Free PMC Article
  3. Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1. Holsclaw JK, et al. Genetics, 2017 May. PMID 28258182, Free PMC Article
  4. An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. Kim S, et al. G3 (Bethesda), 2015 Nov 23. PMID 26596648, Free PMC Article
  5. The XNP remodeler targets dynamic chromatin in Drosophila. Schneiderman JI, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706533, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila.
    Title: The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila.
  2. limination of the ATP-binding activity of Marcal1 also reduced annealing-dependent repair, suggesting that the annealing activity requires translocation along DNA. Unlike the null mutant, however, the ATP-binding defect mutant showed reduced end joining, shedding light on the interaction between SDSA and end-joining pathways.
    Title: Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1.
  3. deficiency of a SMARCAL1 ortholog altering the chromatin structure of a gene
    Title: Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA/DNA annealing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent DNA/DNA annealing activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent DNA/DNA annealing activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA rewinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in replication fork reversal IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Marcal1
Names
CG3753-PA
Marcal1-PA
dsmarcal1
hepA-related protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4955509..4958292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135039.2 → NP_608883.1  Marcal1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMX6
    Related
    FBpp0078631
    Conserved Domains (4) summary
    smart00487
    Location:239 → 420
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:265 → 394
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:518 → 632
    Helicase_C; Helicase conserved C-terminal domain
    pfam07443
    Location:160 → 215
    HARP; HepA-related protein (HARP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMX6.2 Q9VMX6

Gene LinkOut

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