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Marcal1 - Marcal1

Enables ATP-dependent DNA/DNA annealing activity and four-way junction helicase activity. Involved in DNA rewinding and heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing. Located in nucleus and polytene chromosome interband. Used to study Schimke immuno-osseous dysplasia. Human ortholog(s) of this gene implicated in Schimke immuno-osseous dysplasia. Orthologous to human SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa