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SelT Selenoprotein T [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33725, updated on 4-Jan-2025

Summary

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Official Symbol
SelTprovided by FlyBase
Official Full Name
Selenoprotein Tprovided by FlyBase
Primary source
FLYBASE:FBgn0031670
Locus tag
Dmel_CG3887
See related
AllianceGenome:FB:FBgn0031670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3887; Dmel\CG3887; SELT
Summary
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Located in endomembrane system. Is expressed in adult head; adult heart; and organism. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See SelT in Genome Data Viewer
Location:
25C1-25C1; 2-15 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5010922..5012127)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5010922..5012127)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Reticulon-like1 Neighboring gene uncharacterized protein Neighboring gene Transcription factor B5 Neighboring gene viking Neighboring gene Collagen type IV alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
  2. Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. Jin K, et al. PLoS Genet, 2020 Jul. PMID 32644988, Free PMC Article
  3. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
  4. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464
  5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
selenoprotein T
Names
CG3887-PA
CG3887-PB
CG3887-PC
SelT-PA
SelT-PB
SelT-PC
SelT-like protein
NP_001260069.1
NP_001260070.1
NP_608897.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5010922..5012127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273141.1 → NP_001260070.1  selenoprotein T, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMV6
    UniProtKB/TrEMBL
    M9PCL4
    Conserved Domains (1) summary
    TIGR02174
    Location:44 → 182
    CXXU_selWTH; selT/selW/selH selenoprotein domain

  2. NM_135053.4 → NP_608897.1  selenoprotein T, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMV6
    UniProtKB/TrEMBL
    M9PCL4
    Related
    FBpp0078639
    Conserved Domains (1) summary
    TIGR02174
    Location:44 → 182
    CXXU_selWTH; selT/selW/selH selenoprotein domain

  3. NM_001273140.1 → NP_001260069.1  selenoprotein T, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260069.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMV6
    UniProtKB/TrEMBL
    M9PCL4
    Conserved Domains (1) summary
    TIGR02174
    Location:44 → 182
    CXXU_selWTH; selT/selW/selH selenoprotein domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCL4 M9PCL4
Q9VMV6.1 Q9VMV6

Gene LinkOut

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