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Col4a1 - Collagen type IV alpha 1

An extracellular matrix structural constituent. Involved in several processes, including basement membrane organization; intestinal epithelial structure maintenance; and post-embryonic digestive tract morphogenesis. Located in basement membrane. Is expressed in several structures, including adult head; adult heart; cortical zone of lymph gland primary lobe; fat body; and hemocyte. Used to study collagen disease and myopathy. Human ortholog(s) of this gene implicated in several diseases, including Alport syndrome (multiple); X-linked deafness 6; artery disease (multiple); benign familial hematuria; and brain small vessel disease 1. Orthologous to several human genes including COL4A1 (collagen type IV alpha 1 chain) and COL4A6 (collagen type IV alpha 6 chain). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa