His3.3A Histone H3.3A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: His3.3Aprovided by FlyBase
Official Full Name: Histone H3.3Aprovided by FlyBase
Primary source: FLYBASE:FBgn0014857
Locus tag: Dmel_CG5825
See related: AllianceGenome:FB:FBgn0014857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5825; dH3.3A; Dmel\CG5825; H3.3; H3.3 A; H3.3A; His-3.3A; His3.3; PH3
Summary: A structural constituent of chromatin. Located in polytene chromosome. Part of nucleosome. Is expressed in Y chromosome loop; embryonic/larval salivary gland; male germline cell; protein body; and testis. Used to study diffuse midline glioma, H3 K27M-mutant. Orthologous to human H3-3A (H3.3 histone A) and H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 25C3-25C3; 2-15 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5055058..5056149)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5055058..5056149)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced histone gene copy number disrupts Drosophila Polycomb function.
Title: Reduced histone gene copy number disrupts Drosophila Polycomb function.
The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.
Title: The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.
DLP and ASF1 are part of a predeposition complex, which is recruited by XNP and is necessary to prevent DNA exposure in the nucleus.
Title: The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation.
Data show that histone null mutation not only extends S phase, but also causes a cell cycle arrest during G2 phase, and thus prevents cells from entering mitosis.
Title: Histone supply regulates S phase timing and cell cycle progression.
FACT and PBAP complexes are recruited to chromatin boundaries in a GAGA factor-dependent manner, and are needed for H3.3 replacement to execute boundary functions.
Title: The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions.
Presence of H3.3K4me in the chromatin of active genes is dispensable for successful transcription in most cells and only plays an important role in reproductive tissues.
Title: Transcription in the absence of histone H3.3.
Histone H3.3 gene may be required to provide postmeiotic histone H3.3 in the male germ line in transition to chromatin packaging in sperm.
Title: Regulation of the expression of histone H3.3 by differential polyadenylation.
describe a mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays
Title: The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Deposition and inheritance of actively modified H3.3 in regulatory regions maintains transcriptionally active chromatin.
Title: Genome-scale profiling of histone H3.3 replacement patterns.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleosome assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed