Rpn11 Regulatory particle non-ATPase 11 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpn11provided by FlyBase
Official Full Name: Regulatory particle non-ATPase 11provided by FlyBase
Primary source: FLYBASE:FBgn0028694
Locus tag: Dmel_CG18174
See related: AllianceGenome:FB:FBgn0028694
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 37B; CG18174; Dmel\CG18174; DmS13; p37B; PSMD14; Q9V3H2; rpn11; RPn11; RPN11; S13; yip5
Summary: Predicted to enable metal-dependent deubiquitinase activity and proteasome binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; ganglia; and larval muscle system. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 25C3-25C3; 2-15 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5058404..5059790, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5058404..5059790, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0195 (e-PCR)
- UniSTS:79280

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal-dependent deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: regulatory particle non-ATPase 11

Names: CG18174-PA; Rpn11-PA; yippee interacting protein 5

NP_608905.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5058404..5059790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135061.4 → NP_608905.1 regulatory particle non-ATPase 11 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608905.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NIU3, Q9V3H2

Related

FBpp0078664

Conserved Domains (1) summary

cd08069
Location:19 → 284

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5