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Ncoa6 Nuclear receptor coactivator 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33761, updated on 9-Dec-2024

Summary

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Official Symbol
Ncoa6provided by FlyBase
Official Full Name
Nuclear receptor coactivator 6provided by FlyBase
Primary source
FLYBASE:FBgn0031698
Locus tag
Dmel_CG14023
See related
AllianceGenome:FB:FBgn0031698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1402; CG14023; Dmel\CG14023; dNCOA6; NcoA6; NCOA6
Summary
Enables transcription coactivator binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ncoa6 in Genome Data Viewer
Location:
25D5-25D6; 2-16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5315290..5326683, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5315290..5326683, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene vrille Neighboring gene long non-coding RNA:CR45730 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44985 Neighboring gene uncharacterized protein Neighboring gene cyclope

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. Qing Y, et al. Elife, 2014 Jul 15. PMID 25027438, Free PMC Article
  2. Yorkie promotes transcription by recruiting a histone methyltransferase complex. Oh H, et al. Cell Rep, 2014 Jul 24. PMID 25017066, Free PMC Article
  3. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
  4. Modulation of Yorkie activity by alternative splicing is required for developmental stability. Srivastava D, et al. EMBO J, 2021 Feb 1. PMID 33320356, Free PMC Article
  5. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recruitment of NcoA6 is necessary and sufficient for transcriptional activation.
    Title: Yorkie promotes transcription by recruiting a histone methyltransferase complex.
  2. Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6
    Title: The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 6
Names
CG14023-PC
CG14023-PD
CG14023-PF
Ncoa6-PC
Ncoa6-PD
Ncoa6-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5315290..5326683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258955.2 → NP_001245884.1  nuclear receptor coactivator 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NES4
    Conserved Domains (1) summary
    pfam13820
    Location:12 → 64
    Nucleic_acid_bd; Putative nucleic acid-binding region

  2. NM_001103618.3 → NP_001097088.3  nuclear receptor coactivator 6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097088.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYV5
    Conserved Domains (1) summary
    pfam13820
    Location:12 → 64
    Nucleic_acid_bd; Putative nucleic acid-binding region

  3. NM_135077.3 → NP_608921.3  nuclear receptor coactivator 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608921.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMS2
    Conserved Domains (1) summary
    pfam13820
    Location:11 → 63
    Nucleic_acid_bd; Putative nucleic acid-binding region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYV5 A8DYV5
M9NES4 M9NES4
Q8MSY0 Q8MSY0
Q9VMS2 Q9VMS2

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