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fusl fuseless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33765, updated on 9-Dec-2024

Summary

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Official Symbol
fuslprovided by FlyBase
Official Full Name
fuselessprovided by FlyBase
Primary source
FLYBASE:FBgn0031702
Locus tag
Dmel_CG14021
See related
AllianceGenome:FB:FBgn0031702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14021; Dmel\CG14021; Fusl
Summary
Involved in clustering of voltage-gated calcium channels; neuromuscular synaptic transmission; and neuron-neuron synaptic transmission. Located in presynaptic membrane and terminal bouton. Is expressed in several structures, including adult head; retina; synaptic neuropil domain; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See fusl in Genome Data Viewer
Location:
25D6-25D6; 2-16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5330470..5338073, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5330470..5338073, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Turandot M Neighboring gene Acyl-CoA synthetase family member 2 Neighboring gene no mechanoreceptor potential C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In search of proteins that are important for synaptic functions in Drosophila visual system. Kim E, et al. J Neurogenet, 2012 Jun. PMID 22283835
  2. Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. Long AA, et al. J Neurosci, 2008 Apr 2. PMID 18385325, Free PMC Article
  3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
  4. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article
  5. Extracellular matrix and its receptors in Drosophila neural development. Broadie K, et al. Dev Neurobiol, 2011 Nov. PMID 21688401, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in clustering of voltage-gated calcium channels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clustering of voltage-gated calcium channels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron-neuron synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fuseless
Names
CG14021-PA
CG14021-PB
CG14021-PC
CG14021-PD
CG14021-PE
CG14021-PF
fusl-PA
fusl-PB
fusl-PC
fusl-PD
fusl-PE
fusl-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5330470..5338073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135079.6 → NP_608923.1  fuseless, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Related
    FBpp0078712
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless

  2. NM_164641.3 → NP_723080.1  fuseless, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless

  3. NM_164640.3 → NP_723079.1  fuseless, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723079.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Related
    FBpp0078713
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless

  4. NM_001258960.2 → NP_001245889.1  fuseless, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245889.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless

  5. NM_001258961.2 → NP_001245890.1  fuseless, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245890.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless

  6. NM_001298697.1 → NP_001285626.1  fuseless, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3S3
    Conserved Domains (1) summary
    pfam15993
    Location:82 → 369
    Fuseless; Fuseless
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3S3 Q7K3S3

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