nompC no mechanoreceptor potential C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nompCprovided by FlyBase
Official Full Name: no mechanoreceptor potential Cprovided by FlyBase
Primary source: FLYBASE:FBgn0016920
Locus tag: Dmel_CG11020
See related: AllianceGenome:FB:FBgn0016920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11020; CG17468; CT30855; Dmel\CG11020; DmNompC; jf24; l(2)25Dc; l(2)jf24; nomp; nompc; Nompc; NompC; NOMPC; ORE-13; TRPN; TRPN1
Summary: Enables mechanosensitive monoatomic cation channel activity. Involved in several processes, including cellular response to mechanical stimulus; mechanosensory behavior; and sensory perception of mechanical stimulus. Located in several cellular components, including dendrite; microtubule; and neuronal cell body. Is expressed in several structures, including adult antennal lobe; adult brain; organism subdivision; sense organ; and sensory neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 25D6-25D7; 2-16 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5346200..5365760)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5346237..5365760)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
Title: Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila.
analysis reveals an ultrastructural pattern of NompC that is structurally and mechanically optimized for the sensory functions of campaniform mechanoreceptors.
Title: Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors.
Drosophila food texture preference requires NOMPC, a TRP-family mechanosensory channel. NOMPC localizes to the sensory dendrites of neurons housed within gustatory sensilla, and is essential for their mechanosensory-evoked responses.
Title: A mechanosensory receptor required for food texture detection in Drosophila.
de novo atomic structure of Drosophila NOMPC determined by single-particle electron cryo-microscopy
Title: Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Study provides evidence that Ankyrin repeats are essential for NOMPC mechanogating; further mechanogating of NOMPC requires the integrity of microtubules associated to the plasma membrane, providing a precedent for a tethered mechanism for mechanotransduction channel activation.
Title: Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.
NOMPC is required for establishing the fine structure of the sensory dendritic compartment.
Title: NOMPC-dependent mechanotransduction shapes the dendrite of proprioceptive neurons.
NOMPC is likely to be a crucial component of mechanotransducers that accounts for mechanotransductions in mechanosensory neurons of Drosophila.
Title: NOMPC is likely a key component of Drosophila mechanotransduction channels.
This study provides strong evidence that the ankyrin-repeat domains of the transient receptor potential channel NOMPC structurally contribute to the membrane-microtubule connecting filaments in Drosophila.
Title: A NOMPC-dependent membrane-microtubule connector is a candidate for the gating spring in fly mechanoreceptors.
The transient receptor potential channels NOMPC, NANCHUNG, and INACTIVE, but not the dmPIEZO channel, are implicated in mechanotransduction and/or signal amplification for the detection of sound by the larval Cho neurons.
Title: Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
Ripped Pocket (rpk), No Mechanoreceptor Potential C (nompC), and NMDA Receptors 1 and 2 (Nmdars) play critical roles in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia.
Title: Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ankyrin binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mechanosensitive monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	NAS Non-traceable Author Statement more info	PubMed
enables mechanosensitive monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	TAS Traceable Author Statement more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to auditory stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of mechanical stimulus	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: no mechanoreceptor potential C

Names: CG11020-PD; CG11020-PE; CG11020-PF; CG11020-PG; CG11020-PH; No Mechano-receptor potential C; No mechanoreceptor potential C; TRPN; lethal(2)25Dc; nompC-PD; nompC-PE; nompC-PF; nompC-PG; nompC-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5346200..5365760

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316380.1 → NP_001303309.1 no mechanoreceptor potential C, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WN65, Q7KIQ2

Conserved Domains (6) summary

cd00204
Location:969 → 1096

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:1393 → 1592

Ion_trans; Ion transport protein

pfam12796
Location:1048 → 1135

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:865 → 915

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:779 → 834

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1009 → 1041

ANK; ANK repeat [structural motif]
NM_078759.4 → NP_523483.2 no mechanoreceptor potential C, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KIQ2, Q9NGR8, Q9VMR4

Conserved Domains (6) summary

cd00204
Location:969 → 1096

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:1393 → 1598

Ion_trans; Ion transport protein

pfam12796
Location:1048 → 1135

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:865 → 915

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:779 → 834

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1009 → 1041

ANK; ANK repeat [structural motif]
NM_001103619.4 → NP_001097089.2 no mechanoreceptor potential C, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097089.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DYV6, Q7KIQ2

Conserved Domains (6) summary

cd00204
Location:969 → 1096

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:1393 → 1563

Ion_trans; Ion transport protein

pfam12796
Location:1048 → 1135

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:865 → 915

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:779 → 834

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1009 → 1041

ANK; ANK repeat [structural motif]
NM_205912.4 → NP_995634.2 no mechanoreceptor potential C, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995634.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KIQ2, Q7KTN8

Conserved Domains (6) summary

cd00204
Location:969 → 1096

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:1393 → 1569

Ion_trans; Ion transport protein

pfam12796
Location:1048 → 1135

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:865 → 915

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:779 → 834

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1009 → 1041

ANK; ANK repeat [structural motif]
NM_001258962.3 → NP_001245891.1 no mechanoreceptor potential C, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245891.1

Status: REVIEWED

UniProtKB/TrEMBL

E0A9E1, Q7KIQ2

Conserved Domains (6) summary

cd00204
Location:969 → 1096

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:1393 → 1569

Ion_trans; Ion transport protein

pfam12796
Location:1048 → 1135

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:865 → 915

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:779 → 834

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1009 → 1041

ANK; ANK repeat [structural motif]