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mid - midline

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription corepressor binding activity. Involved in several processes, including generation of neurons; heart development; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; epidermis; follicle cell; imaginal disc; and segmentally-repeated neuroblast. Used to study cardiomyopathy and congenital heart disease. Human ortholog(s) of this gene implicated in atrial heart septal defect; atrial heart septal defect 4; congenital heart disease; tetralogy of Fallot; and ventricular septal defect. Orthologous to human TBX20 (T-box transcription factor 20). [provided by Alliance of Genome Resources, Dec 2024]

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NCBI Orthologs

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Species Gene Architecture aa