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CG14020 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33771, updated on 4-Jan-2025

Summary

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Official Symbol
CG14020provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031707
Locus tag
Dmel_CG14020
See related
AllianceGenome:FB:FBgn0031707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14020
Summary
Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to be active in ciliary membrane and ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG14020 in Genome Data Viewer
Location:
25E5-25E5; 2-17 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5517737..5518949)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5517737..5518949)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midline Neighboring gene long non-coding RNA:CR45287 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44793 Neighboring gene Vacuolar protein sorting 52 Neighboring gene clot Neighboring gene Elongator complex protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
  2. The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Miskolczi-McCallum CM, et al. Dev Biol, 2005 Feb 15. PMID 15680363
  3. Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. Kondylis V, et al. PLoS One, 2011 Feb 23. PMID 21383842, Free PMC Article
  4. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Halfon MS, et al. Genome Res, 2002 Jul. PMID 12097338, Free PMC Article
  5. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14020-PA
CG14020-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5517737..5518949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135084.4 → NP_608928.1  uncharacterized protein Dmel_CG14020, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMR1
    Related
    FBpp0078727
    Conserved Domains (1) summary
    pfam10149
    Location:1 → 318
    TM231; Transmembrane protein 231

  2. NM_001273168.2 → NP_001260097.1  uncharacterized protein Dmel_CG14020, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB43
    Conserved Domains (1) summary
    pfam10149
    Location:1 → 318
    TM231; Transmembrane protein 231
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB43 M9PB43
Q9VMR1 Q9VMR1

Gene LinkOut

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