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FCGRT Fc gamma receptor and transporter [ Bos taurus (domestic cattle) ]

Gene ID: 338062, updated on 27-Dec-2024

Summary

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Official Symbol
FCGRTprovided by VGNC
Official Full Name
Fc gamma receptor and transporterprovided by VGNC
Primary source
VGNC:VGNC:28934
See related
BGD:BT11421; Ensembl:ENSBTAG00000013926
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See FCGRT in Genome Data Viewer
Location:
chromosome: 18
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55961575..55968122)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD35 Neighboring gene ribosomal protein S11 Neighboring gene microRNA mir-150 Neighboring gene reticulocalbin 3 Neighboring gene uncharacterized LOC132342713 Neighboring gene nitric oxide synthase interacting protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice. Szikora B, et al. Front Immunol, 2020. PMID 32973781, Free PMC Article
  2. Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice. Cui D, et al. PLoS One, 2014. PMID 25546424, Free PMC Article
  3. Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum. Zhang R, et al. Anim Biotechnol, 2009. PMID 19937499
  4. Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo. Sayed-Ahmed A, et al. Acta Histochem, 2010 Jul. PMID 19481783
  5. Isolation of the gene encoding the bovine neonatal Fc receptor. Doleschall M, et al. Vet Immunol Immunopathol, 2005 Oct 18. PMID 16095719

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice.
    Title: FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice.
  2. The transport of IgGs in the mammary gland, by FcRn, was investigated.
    Title: Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice.
  3. The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
    Title: Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo.
  4. haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
    Title: Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum.
  5. FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
    Title: Isolation of the gene encoding the bovine neonatal Fc receptor.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-2-microglobulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment of IgG receptor and transporter
Fc fragment of IgG, receptor, transporter, alpha
Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176657.1 → NP_788830.1  IgG receptor FcRn large subunit p51 precursor

    See identical proteins and their annotated locations for NP_788830.1

    Status: PROVISIONAL

    Source sequence(s)
    AF139106
    UniProtKB/TrEMBL
    A0AAA9RWF7, Q3T119
    Related
    ENSBTAP00000031824.3, ENSBTAT00000031878.3
    Conserved Domains (2) summary
    cl08246
    Location:29 → 196
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:200 → 290
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55961575..55968122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024977965.1 → XP_024833733.1  IgG receptor FcRn large subunit p51 isoform X1

    UniProtKB/TrEMBL
    A0AAA9RWF7, F6R592
    Related
    ENSBTAP00000018500.3, ENSBTAT00000018500.4
    Conserved Domains (2) summary
    cl08246
    Location:40 → 207
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:211 → 301
    Ig; Immunoglobulin domain

  2. XM_005219176.5 → XP_005219233.1  IgG receptor FcRn large subunit p51 isoform X2

    See identical proteins and their annotated locations for XP_005219233.1

    UniProtKB/TrEMBL
    A0AAA9RWF7, Q3T119
    Related
    ENSBTAP00000040745.1, ENSBTAT00000043155.2
    Conserved Domains (2) summary
    cl08246
    Location:29 → 196
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:200 → 290
    Ig; Immunoglobulin domain

  3. XM_005219175.5 → XP_005219232.1  IgG receptor FcRn large subunit p51 isoform X2

    See identical proteins and their annotated locations for XP_005219232.1

    UniProtKB/TrEMBL
    A0AAA9RWF7, Q3T119
    Conserved Domains (2) summary
    cl08246
    Location:29 → 196
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:200 → 290
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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