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eIF4A - eukaryotic translation initiation factor 4A

Enables SMAD binding activity. Involved in several processes, including female germ-line stem cell asymmetric division; pole cell formation; and regulation of alternative mRNA splicing, via spliceosome. Located in P granule and cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; imaginal disc; and larval brain. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to several human genes including EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa